{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:39:30Z","timestamp":1694464770915},"reference-count":37,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Warthin's tumors of the parotid gland are associated with smoking, whereas pleomorphic adenomas are not. Genetic polymorphisms in biotransformation enzymes, involved in detoxification of toxins and carcinogens in cigarette smoke, might modify the corresponding enzyme activity and influence detoxifying capacity. We hypothesize that these genetic polymorphisms may influence the individual risk for Warthin's tumor, but not for pleomorphic adenomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood from 146 patients with benign parotid gland tumors and 437 controls were investigated for polymorphisms in several biotransformation enzymes. Based on these polymorphisms, patients and controls were divided according to predicted enzyme activity (low, intermediate, and high).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of predicted intermediate and high activity <jats:italic>UGT1A7<\/jats:italic> and <jats:italic>UGT1A6<\/jats:italic> genotypes was significantly higher in the patients with Warthin's tumors, but not in patients with pleomorphic adenomas, compared with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Predicted intermediate and high activity <jats:italic>UGT1A7<\/jats:italic> and <jats:italic>UGT1A6<\/jats:italic> genotypes are associated with an increased risk for Warthin's tumor. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E717\u2013E723, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24077","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T22:50:49Z","timestamp":1429570249000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic polymorphisms in <i>UDP\u2010glucuronosyltransferase 1A6<\/i> and <i>1A7<\/i> and the risk for benign Warthin's tumors of the parotid gland"],"prefix":"10.1002","volume":"38","author":[{"given":"Martin","family":"Lacko","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri C.","family":"Voogd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rens C.E.","family":"van de Goor","sequence":"additional","affiliation":[{"name":"Department 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