{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:31:41Z","timestamp":1777620701907,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T00:00:00Z","timestamp":1437177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kosin University College of Medicine, Busan, Republic of South Korea."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have reported the expression of the melanoma\u2010associated antigen (MAGE) gene in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the correlations between MAGE expression in sputum and the clinical features and oncologic outcomes of SCC of the larynx and hypopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of 119 patients treated for SCC of the larynx and hypopharynx and analysis of their induced sputum by nested reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) to detect the MAGE\u2010A1\u20136 gene. The associations between MAGE expression and clinical characteristics were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Expression of MAGE\u2010A1\u20136 in sputum was identified in 57 of 119 patients (47.9%), and was independently correlated to double primary cancer (<jats:italic>p<\/jats:italic>\u2009=\u2009.024; odds ratio [OR]\u2009=\u20094.135). Expression of MAGE\u2010A1\u20136 in sputum was correlated to poor survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Expression of MAGE\u2010A1\u20136 in sputum predicts poor oncologic outcome in patients with SCC of the larynx and hypopharynx. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E736\u2013E740, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24081","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T22:48:49Z","timestamp":1429570129000},"source":"Crossref","is-referenced-by-count":4,"title":["Clinical significance of melanoma\u2010associated antigen A1\u20136 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx"],"prefix":"10.1002","volume":"38","author":[{"given":"Kang Dae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kosin University College of Medicine  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Shin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kosin University College of Medicine  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kosin University College of Medicine  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taejung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kosin University College of Medicine  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Chul","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Dong\u2010A University College of Medicine  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology Kosin University College of Medicine  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Bong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Gimhae College  Busan Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ho","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Catholic University of Daegu School of Medicine  Daegu Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Keimyung University  Daegu Republic of South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23724"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21880"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25607"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20380"},{"key":"e_1_2_5_6_1","first-page":"5037","article-title":"Expression of the MAGE 3 gene product in squamous cell carcinomas of the head and neck","volume":"19","author":"Lee KD","year":"1999","journal-title":"Anticancer Res"},{"key":"e_1_2_5_7_1","first-page":"1513","article-title":"Expression of MAGE A 1\u20136 mRNA in sputa of head and neck cancer patients\u2010a preliminary report","volume":"26","author":"Lee KD","year":"2006","journal-title":"Anticancer 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