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Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had \u22651% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with &lt;1% ACs in the first sample had \u22651% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow\u2010up. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E741\u2013E746, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24086","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T22:53:52Z","timestamp":1429570432000},"source":"Crossref","is-referenced-by-count":8,"title":["Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow\u2010up analysis"],"prefix":"10.1002","volume":"38","author":[{"given":"Ran","family":"Yahalom","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Yarom","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The 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