{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:49:50Z","timestamp":1783468190055,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bartley-Smith\/Wharton, the Gordon Tozer and the Petersen Funds at the Princess Margaret Cancer Foundation","award":["Internal"],"award-info":[{"award-number":["Internal"]}]},{"name":"Princess Margaret Cancer Foundation - Department of Radiation Oncology Academic Enrichment Fund","award":["Internal"],"award-info":[{"award-number":["Internal"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Salivary duct carcinoma is rare, with distinct morphology and behavior. We reviewed our institutional experience with salivary duct carcinoma, aiming to characterize clinical behavior and treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All salivary duct carcinomas treated curatively between 1999 and 2010 were reviewed. Overall survival (OS), locoregional control, distant control, and patterns of failure were analyzed. Multivariate analysis identified predictors of OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four patients with salivary duct carcinoma (parotid gland = 49; submandibular gland = 5) were included in the analysis. Fifty\u2010three patients underwent primary surgery, and 48 (89%) received postoperative radiotherapy (RT; median dose = 60 Gy). Median follow\u2010up was 5.7 years. The 5\u2010year OS, locoregional control, and distant control were 43%, 70%, and 48%, respectively. Nine local (6 involving facial nerve), 10 regional, and 28 distant failures were identified. Multiple pathologic involved lymph nodes (pN2b\/N2c) predicted reduced OS (hazard ratio [HR] = 3.6; <jats:italic>p<\/jats:italic> = .02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distant recurrence is common. Presence of pN2b\/N2c disease is associated with reduced OS. Local recurrence frequently involves the facial nerves. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E820\u2013E826, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24107","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T02:29:14Z","timestamp":1430188154000},"source":"Crossref","is-referenced-by-count":72,"title":["Salivary duct carcinoma: Treatment, outcomes, and patterns of failure"],"prefix":"10.1002","volume":"38","author":[{"given":"Meredith L.","family":"Johnston","sequence":"first","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshetu G.","family":"Atenafu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University Health Network Princess Margaret Cancer Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University of Toronto Toronto Ontario 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