{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:28:52Z","timestamp":1791188932452,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005193","name":"American Academy of Otolaryngology-Head and Neck Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["CA12587-06"],"award-info":[{"award-number":["CA12587-06"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["T32-GM008616"],"award-info":[{"award-number":["T32-GM008616"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bony non\u2010unions arising in the aftermath of collateral radiation injury are commonly managed with vascularized free tissue transfers. Unfortunately, these procedures are invasive and fraught with attendant morbidities. This study investigated a novel, alternative treatment paradigm utilizing adipose\u2010derived stem cells (ASCs) combined with angiogenic deferoxamine (DFO) in the rat mandible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats were exposed to a bioequivalent dose of radiation and mandibular osteotomy. Those exhibiting non\u2010unions were subsequently treated with surgical debridement alone or debridement plus combination therapy. Radiographic and biomechanical outcomes were assessed after healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant increases in biomechanical strength and radiographic metrics were observed in response to combination therapy (<jats:italic>p<\/jats:italic> &lt; .05). Importantly, combined therapy enabled a 65% reduction in persisting non\u2010unions when compared to debridement alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We support the continued investigation of this promising combination therapy in its potential translation for the management of radiation\u2010induced bony pathology. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E837\u2013E843, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24110","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T02:28:03Z","timestamp":1430188083000},"source":"Crossref","is-referenced-by-count":7,"title":["Translational treatment paradigm for managing non\u2010unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic 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