{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T11:21:00Z","timestamp":1722856860868},"reference-count":26,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate the tolerability of concurrent radiotherapy and cetuximab (bioradiotherapy [BRT]) after taxane\u2010based induction chemotherapy in head and neck squamous cell carcinoma (HNSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred four patients with HNSCC received BRT with (29%) or without (71%) prior taxane\u2010based induction chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Radiodermatitis (97%) and skin rash (65%) occurred frequently, but there was no difference of occurrence or the grade of the rash observed in the 2 populations. However, patients receiving taxane\u2010based induction chemotherapy had a less severe rash as compared with patients without induction chemotherapy. Mucositis and dysphagia were frequent and comparable in the 2 groups. The occurrence of a skin rash (at any grade) did not predict an increased overall survival (OS) in the overall population, but it was associated with an improved 3\u2010year OS in patients receiving taxane\u2010based induction chemotherapy. OS was not influenced by the skin rash grade in the overall population of the 2 treatment subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taxane\u2010based induction chemotherapy did not increase the rate of cetuximab\u2010related toxicities. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E905\u2013E910, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24125","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T23:32:47Z","timestamp":1431559967000},"source":"Crossref","is-referenced-by-count":8,"title":["Toxicity of concomitant cetuximab and radiotherapy with or without initial taxane\u2010based induction chemotherapy in locally advanced head and neck cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Antonin","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Gustave Roussy Villejuif, Universit\u00e9 Paris Sud 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