{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:38:48Z","timestamp":1694464728427},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether initial clinical presentation and thyroid ultrasonography referral indications can significantly predict malignant\/suspicious for malignancy (Bethesda System for Reporting Thyroid Cytopathology [Bethesda] V\/VI) thyroid ultrasound\u2010guided fine\u2010needle aspiration (FNA) cytology results is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2010 and May 2014, we performed 705 thyroid ultrasound\u2010guided FNA biopsies, according to the American Thyroid Association (ATA) guidelines. Univariate analysis was used to identify significant predictors for Bethesda V\/VI thyroid ultrasound\u2010guided FNA cytology, including age, sex, imaging modality, thyroid dysfunction, neck pain, breathing difficulties, dysphagia, odynophagia, fatigue, lateral cervical mass, parotid mass, and hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty percent of patients were referred to thyroid ultrasound\u2010guided FNA because of thyroid incidentalomas and 40% because of palpable thyroid nodules found on physical examination. Only positron emission tomography (PET)\u2010CT emerged as being a significant predictor for Bethesda V\/VI thyroid ultrasound\u2010guided FNA cytology (odds ratio [OR]\u2009=\u20095.64; 95% confidence interval [CI]\u2009=\u20091.16\u201327.33; <jats:italic>p =<\/jats:italic> .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patient symptomatology and initial clinical thyroid ultrasound\u2010guided FNA referral indications cannot predict the nature of thyroid nodules. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E991\u2013E995, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24143","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T07:32:52Z","timestamp":1433403172000},"source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of clinical presentation and referral indications for ultrasound\u2010guided fine\u2010needle aspiration biopsy of the thyroid as possible predictors of thyroid cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Sara","family":"Abu\u2010Ghanem","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery Tel\u2010Aviv Sourasky Medical Center Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Kaplan Medical Center Hadassah School of Medicine, Hebrew University Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lazutkin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Kaplan Medical Center Hadassah School of Medicine, Hebrew University Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Abu\u2010Ghanem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery Tel\u2010Aviv Sourasky Medical Center Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M.","family":"Fliss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery Tel\u2010Aviv Sourasky Medical Center Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Yehuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery Tel\u2010Aviv Sourasky Medical Center Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"SEER Cancer Statistics Review 1975\u20132010","author":"Howlader N","year":"2012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0045"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0257"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814524705"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.9245"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.10.1367"},{"key":"e_1_2_6_10_1","first-page":"209","article-title":"Thyroid nodules: risk stratification for malignancy with ultrasound and guided biopsy","volume":"11","author":"Anil G","year":"2011","journal-title":"Cancer Imaging"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1207-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.05.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072504322783812"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23273"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9503-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0124.x"},{"key":"e_1_2_6_18_1","first-page":"e299","article-title":"Do family physicians request ultrasound scans appropriately?","volume":"57","author":"Landry BA","year":"2011","journal-title":"Can Fam Physician"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11019-010-9233-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/17.1.46"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2006.04.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2005.02.013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1622"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:52:51Z","timestamp":1694310771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":22,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/hed.24143"],"URL":"https:\/\/doi.org\/10.1002\/hed.24143","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]}}}