{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:01:46Z","timestamp":1784091706826,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T00:00:00Z","timestamp":1437177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National High Technology Research and Development Program of China","award":["863 Program; 2012AA02A210"],"award-info":[{"award-number":["863 Program; 2012AA02A210"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["Y13H16011"],"award-info":[{"award-number":["Y13H16011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate the potential relationship between Hashimoto's thyroiditis and BRAF<jats:sup>V600E<\/jats:sup> mutation status in patients with papillary thyroid carcinoma (PTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 619 patients with PTC who underwent total thyroidectomy with lymph node dissection were enrolled in this study. Univariable and multivariate analyses were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hashimoto's thyroiditis was present in 35.9% (222 of 619) of PTCs. Multivariate logistic regressions showed that BRAF<jats:sup>V600E<\/jats:sup> mutation, sex, extrathyroidal extension, and lymph node metastasis were independent factors for Hashimoto's thyroiditis. Female sex, more frequent extrathyroidal extension, and a higher incidence of lymph node metastasis were significantly associated with PTCs accompanied by BRAF<jats:sup>V600E<\/jats:sup> mutation without Hashimoto's thyroiditis compared with PTCs accompanied by BRAF<jats:sup>V600E<\/jats:sup> mutation with Hashimoto's thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hashimoto's thyroiditis was negatively associated with BRAF<jats:sup>V600E<\/jats:sup> mutation, extrathyroidal extension, and lymph node metastasis. In addition, Hashimoto's thyroiditis was related to less lymph node metastasis and extrathyroidal extension in PTCs with BRAF<jats:sup>V600E<\/jats:sup> mutation. Therefore, Hashimoto's thyroiditis is a potentially protective factor in PTC. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1019\u2013E1025, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24149","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T01:29:53Z","timestamp":1433381393000},"source":"Crossref","is-referenced-by-count":27,"title":["Potential relationship between Hashimoto's thyroiditis and BRAF<sup>V600E<\/sup> mutation status in papillary thyroid cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Rui\u2010chao","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang\u2010ping","family":"Jin","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University Wenzhou 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