{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:06:21Z","timestamp":1791378381750,"version":"4.3.2"},"reference-count":38,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T00:00:00Z","timestamp":1437177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang Gung Memorial Hospital, Taiwan","award":["CMRPG8A0201"],"award-info":[{"award-number":["CMRPG8A0201"]}]},{"name":"Chang Gung Memorial Hospital, Taiwan","award":["CMRPG8A0202"],"award-info":[{"award-number":["CMRPG8A0202"]}]},{"name":"Chang Gung Memorial Hospital, Taiwan","award":["CMRPG8C1141"],"award-info":[{"award-number":["CMRPG8C1141"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate late toxicities and quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) with long\u2010term survival after treatment by intensity\u2010modulated radiotherapy (IMRT) versus non\u2010IMRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational, cross\u2010sectional study of QOL and late toxicities was conducted in 242 patients with NPC with survival of &gt;5 years after treatment with IMRT (<jats:italic>n<\/jats:italic>\u2009=\u2009100) or non\u2010IMRT (<jats:italic>n<\/jats:italic>\u2009=\u2009142) by using physician\u2010assessed toxicities (Common Terminology Criteria for Adverse Events [CTCAE] version 4) and the patient\u2010reported European Organization for Research and Treatment of Cancer Quality of Life Questionnaire\u2010Core 30\u2010questions (EORTC QLQ\u2010C30) and the Head and Neck 35\u2010questions (EORTC QLQ\u2010C30\u2010H&amp;N35) module.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IMRT group had both statistically (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and clinically (difference of predicted mean scores \u226510 points) better outcome in global QOL, cognitive functioning, social functioning, fatigue, and 11 scales of the head and neck module. Late toxicities, including neuropathy, hearing loss, dysphagia, xerostomia, and neck fibrosis were significantly less severe in the IMRT group. Multivariate analysis revealed that the radiotherapy (RT) technique was statistically significantly associated with late toxicities and QOL outcome after adjusting for other clinical and demographic variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of the IMRT technique was associated with the improvement of physician\u2010assessed late toxicities and patient\u2010reported QOL in NPC survivors. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1026\u2013E1032, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24150","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T01:29:26Z","timestamp":1433381366000},"source":"Crossref","is-referenced-by-count":66,"title":["Long\u2010term late toxicities and quality of life for survivors of nasopharyngeal carcinoma treated with intensity\u2010modulated radiotherapy versus non\u2013intensity\u2010modulated radiotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Tai\u2010Lin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yen","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ling","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Cosmetics and Fashion Styling Cheng Shiu University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Cho","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital 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