{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:16Z","timestamp":1792686016340,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pleomorphic adenoma is the most frequent salivary gland tumor and is known for its tendency to recur and for its ability to transform to carcinoma ex pleomorphic adenoma (Ca\u2010ex\u2010PA). Along with pleomorphic adenoma demographics, we present the first nationwide study with long\u2010term follow\u2010up on these topics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Danish Pathology Data Bank was searched for parotid pleomorphic adenoma and Ca\u2010ex\u2010PA in the period 1985 to 2010 and all pathology descriptions were reviewed. Ca\u2013ex\u2013PA specimens were reviewed by a pathologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5.497 patients were identified and 2.86% had at least one recurrence. An incidence of 4.29\/100,000\/year was found. The rate of malignant transformation in recurrent pleomorphic adenoma was 3.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report an up\u2010to\u2010date assessment of the epidemiology of pleomorphic adenoma. We found an increasing incidence and low recurrence rate compared with previous studies. The risk of Ca\u2010ex\u2010PA for patients with recurrent pleomorphic adenoma was low compared to the literature. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1364\u2013E1369, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24228","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T15:26:34Z","timestamp":1442589994000},"source":"Crossref","is-referenced-by-count":99,"title":["Pleomorphic adenoma of the parotid gland 1985\u20132010: A Danish nationwide study of incidence, recurrence rate, and malignant transformation"],"prefix":"10.1002","volume":"38","author":[{"given":"Simon","family":"Andreasen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery K\u00f8ge University Hospital K\u00f8ge Denmark"},{"name":"Department of Otolaryngology Head and Neck Surgery and Audiology Rigshospitalet Copenhagen Denmark"},{"name":"University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne H.","family":"Therkildsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Bj\u00f8rndal","sequence":"additional","affiliation":[{"name":"Department of ORL\u2013Head and Neck Surgery Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben","family":"Hom\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery K\u00f8ge University Hospital K\u00f8ge Denmark"},{"name":"University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"254","volume-title":"World Health Organization Classification of Tumours. 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