{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:28Z","timestamp":1761823768619},"reference-count":26,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to assess the use of sentinel lymph node biopsy (SLNB) in clinically lymph node\u2013negative (cN0) squamous cell carcinoma (SCC) of the lip deemed high risk for occult nodal metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients with cT1 to T2 cN0 with SCC of the lip underwent SLNB at a tertiary referral center between January 2001 and March 2012. Initial staging methods were clinical examination only (65.4%), ultrasound (23.1%), or CT (11.5%). Operations were performed with the patients under local anesthesia with sedation (50%) or general anesthesia (50%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up time was 53 months. Three patients (11.5%) had a positive sentinel node and were upstaged. One SLNB\u2010related complication was observed. Regional recurrence occurred in 2 patients (7.7%). The relationship between regional status and both tumor diameter and tumor thickness was statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLNB can be a viable staging technique in SCC of the lip. Tumor diameter of\u2009\u2265\u200920\u2009mm and increasing tumor thickness seem to delineate higher risk for regional disease in our study. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1375\u2013E1380, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24230","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T05:45:14Z","timestamp":1446183914000},"source":"Crossref","is-referenced-by-count":12,"title":["Sentinel lymph node biopsy in cN0 squamous cell carcinoma of the lip: A retrospective study"],"prefix":"10.1002","volume":"38","author":[{"given":"Erik Mikael Jan","family":"Sollamo","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, T\u00f6\u00f6l\u00f6 Hospital Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvi Kristiina","family":"Ilmonen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, T\u00f6\u00f6l\u00f6 Hospital Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Susanna","family":"Virolainen","sequence":"additional","affiliation":[{"name":"Haartman Institute of Pathology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinikka Hilkka Helena","family":"Suominen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, T\u00f6\u00f6l\u00f6 Hospital Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30844-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20576"},{"key":"e_1_2_7_4_1","unstructured":"Finnish Cancer Registry. 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