{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:28:59Z","timestamp":1786933739231,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The floor of mouth (FOM) is a common site of oral squamous cell carcinoma (SCC). The purpose of this study was to investigate pathological predictors of survival in FOM SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of 54 consecutive patients undergoing surgery for FOM SCC. Pathological parameters were extracted from histological reports with original pathology slides re\u2010reviewed by 2 pathologists for missing data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On univariate analysis, depth of invasion &gt;10 mm (<jats:italic>p<\/jats:italic> = .009), lymphovascular invasion (LVI; <jats:italic>p<\/jats:italic> &lt; .001), noncohesive invasive front (<jats:italic>p<\/jats:italic> = .006), perineural invasion (PNI; <jats:italic>p<\/jats:italic> = .003), and nodal metastases (<jats:italic>p<\/jats:italic> = .02) were significant predictors of overall survival. On multivariate analysis, LVI (<jats:italic>p<\/jats:italic> = .009) and invasive front (<jats:italic>p<\/jats:italic> &lt; .001) remained significant. Postoperative radiotherapy improved survival in patients with LVI, PNI, and nodal metastases, and was just outside significance for noncohesive invasive front (<jats:italic>p<\/jats:italic> = .06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LVI is an adverse prognosticator in FOM SCC and indicates postoperative radiotherapy. Further study is required to investigate the importance of invasive front. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1528\u2013E1534, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24273","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T14:14:50Z","timestamp":1448460890000},"source":"Crossref","is-referenced-by-count":34,"title":["Importance of lymphovascular invasion and invasive front on survival in floor of mouth cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Cassie","family":"Fives","sequence":"first","affiliation":[{"name":"Department of Pathology Cork University Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Feeley","sequence":"additional","affiliation":[{"name":"Department of Pathology Cork University Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery South Infirmary Victoria University Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sheahan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery South Infirmary Victoria University Hospital Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23952"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200010000-00038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199708)19:5<400::AID-HED6>3.0.CO;2-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814551718"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1993.tb00125.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3283592cce"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.09.012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90303-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.10.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149687.90710.21"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24459"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.849818"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.10.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20036"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23380"},{"key":"e_1_2_7_19_1","unstructured":"HelliwelT WoolgarJA.Dataset for histopathology reporting of mucosal malignancies of the oral cavity. 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