{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:34:34Z","timestamp":1767598474488},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence\u2010free survival (RFS) according to histologic grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low\u2010grade cancer (<jats:italic>p<\/jats:italic> = .049 and <jats:italic>p<\/jats:italic> = .019, respectively), whereas perineural invasion was the only significant factor in patients with high\u2010grade cancer (<jats:italic>p<\/jats:italic> = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low\u2010grade cancer (8.3%) and distant at high\u2010grade cancer (13.6%). The duration of RFS was significantly longer in low\u2010grade cancer than high\u2010grade cancer in regional and distant recurrence (<jats:italic>p<\/jats:italic> = .044 and <jats:italic>p<\/jats:italic> = .016, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consideration of different factors may be required for individual low\u2010grade and high\u2010grade parotid cancers when predicting the risk of recurrence. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1788\u2013E1793, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24316","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T05:22:40Z","timestamp":1450934560000},"source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathologic factors associated with recurrence in low\u2010 and high\u2010grade parotid cancers"],"prefix":"10.1002","volume":"38","author":[{"given":"Doh Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer Hallym University, College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Gu","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Korea University College of Medicine Seoul South 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