{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:48:50Z","timestamp":1771026530599,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary inverted papillomas of the middle ear are extremely rare tumors, with only few cases published in the literature. They have a characteristic epithelium surface inversion to the inside of the stroma. Inverted papillomas are benign lesions but have a high propensity of recurrence, local aggressiveness, and association with malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a patient with an inverted papilloma originating in the middle ear producing chronic otorrhea and facial nerve palsy treated with a subtotal petrosectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up, the patient developed an intracranial invasion of the tumor causing his death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary inverted papillomas of the middle ear can have an extremely aggressive behavior despite their benign characteristics; therefore, an aggressive treatment must be performed in order to minimize the possibility of recurrence. \u00a9 2015 Wiley Periodicals, Inc. Head Neck 38: E105\u2013E107, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24329","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T05:23:21Z","timestamp":1450934601000},"source":"Crossref","is-referenced-by-count":10,"title":["Primary inverted papilloma of the middle ear with intracranial invasion"],"prefix":"10.1002","volume":"38","author":[{"given":"Andr\u00e9s","family":"Coca\u2010Pelaz","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justo","family":"G\u00f3mez\u2013Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Vivanco\u2013Allende","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Hermsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Llorente","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"Doc12","article-title":"Intracranial extension of Schneiderian inverted papilloma: a case report and literature review","volume":"10","author":"Pitak\u2013Arnnop P","year":"2012","journal-title":"Ger Med Sci"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000205"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200309000-00026"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3280803d9b"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199801)20:1<83::AID-HED14>3.0.CO;2-Q"},{"key":"e_1_2_4_7_1","first-page":"28","volume-title":"World Health Organization classification of tumours. 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