{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:15:24Z","timestamp":1789866924949,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sydney Cancer Center Grant, Sydney Breast Cancer Foundation and the philanthropic support from Mr. David Paradice, the Tag Family Foundation, the O'Sullivan family, the Wald family, and ICAP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate diagnosis of salivary duct carcinoma requires a high index of suspicion and clinicopathologic correlation. Hallmark genetic changes that may provide novel therapeutic options are being explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred ninety salivary gland malignancies at Royal Prince Alfred Hospital (from 1989\u20132014) were reviewed. Human epidermal growth factor receptor 2 (HER2) and androgen receptor status were determined along with multigene profiling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three salivary duct carcinomas were identified, predominantly in men in their fifth to ninth decades of life. Facial nerve palsy (12%) and cervical lymph node metastases (82%) were present, and 96% received postoperative adjuvant therapy. Histologically, the tumors resembled high\u2010grade invasive and in situ ductal carcinoma of the breast. Micropapillary, papillary, sarcomatoid, oncocytic, and mucinous variants were seen. The tumors showed androgen receptor (70%), <jats:italic>HER2<\/jats:italic> amplification (30%), and <jats:italic>HRAS<\/jats:italic>, <jats:italic>AKT1<\/jats:italic>, <jats:italic>PIK3CA<\/jats:italic>, and <jats:italic>NRAS<\/jats:italic> mutations (22%; cumulative). The 5\u2010year disease\u2010free survival was 36%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary duct carcinoma demonstrates a wide histopathologic spectrum. Treatment strategies need to take androgen receptor, <jats:italic>HER2<\/jats:italic> amplification, and <jats:italic>PIK3CA<\/jats:italic> mutation into account. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1838\u2013E1847, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24332","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T05:24:46Z","timestamp":1450934686000},"source":"Crossref","is-referenced-by-count":61,"title":["Salivary duct carcinoma: Clinicopathologic features, morphologic spectrum, and somatic mutations"],"prefix":"10.1002","volume":"38","author":[{"given":"Peter P.","family":"Luk","sequence":"first","affiliation":[{"name":"Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared D.","family":"Weston","sequence":"additional","affiliation":[{"name":"Westmead Hospital Sydney 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