{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:01:25Z","timestamp":1761541285237},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,12,26]],"date-time":"2015-12-26T00:00:00Z","timestamp":1451088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate the long\u2010term results of primary radiotherapy treatment for squamous cell carcinoma (SCC) of the nasal vestibule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010one patients were treated with external beam radiotherapy (EBRT) and\/or interstitial radiotherapy (IRT) for a primary, localized, Wang classified SCC of the nasal vestibule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 38 months. T1 tumors were treated with IRT: we observed 1 local failure (at 13 months) among 48 patients (5\u2010year local control rate of 97%). Most T2 tumors (20 of 26) were treated with EBRT. There were 8 local recurrences among 26 patients (5\u2010year local control rate of 68%). For the T3 tumors (<jats:italic>n<\/jats:italic> = 7; all treated with EBRT), we observed local recurrence in 2 patients (5\u2010year local control rate of 53%). The late\u2010term side effects were relatively mild.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local primary radiotherapy (either IRT for T1 or EBRT for T2\/3) is an adequate treatment for SCC of the nasal vestibule with little late sequelae. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E1870\u2013E1875, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24337","type":"journal-article","created":{"date-parts":[[2015,12,26]],"date-time":"2015-12-26T06:14:40Z","timestamp":1451110480000},"source":"Crossref","is-referenced-by-count":14,"title":["Irradiation of localized squamous cell carcinoma of the nasal vestibule"],"prefix":"10.1002","volume":"38","author":[{"given":"Ben G. L.","family":"Vanneste","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Lopez\u2013Yurda","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Statistics The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. Bing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons J. M.","family":"Balm","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerben R.","family":"Borst","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen R.","family":"Rasch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<100::AID-CNCR2820380118>3.0.CO;2-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10023"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100119425"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(88)90052-7"},{"key":"e_1_2_6_6_1","volume-title":"DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology","author":"DeVita VT","year":"2008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31815aff1f"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23758"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.03.041"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199908)21:5<385::AID-HED2>3.0.CO;2-R"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.01.007"},{"key":"e_1_2_6_12_1","first-page":"284","volume-title":"Principles and practice of brachytherapy using afterloading systems","author":"Gerbaulet A","year":"2001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21132"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860230101034"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002259"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.10.016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3043799"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2007.01353.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21570"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24337","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:05:08Z","timestamp":1694311508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,26]]},"references-count":18,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/hed.24337"],"URL":"https:\/\/doi.org\/10.1002\/hed.24337","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,26]]}}}