{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:37:19Z","timestamp":1779374239038,"version":"3.53.1"},"reference-count":16,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high\u2010grade sarcomatous change found only in lesions with prior radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We describe the first reported case of high\u2010grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45\u2010year\u2010old man presented with left\u2010sided nasal congestion and fullness and was found to have a left\u2010sided nasopharyngeal mass with intracranial extension on CT scan. A biopsy of the mass revealed nasopharyngeal angiofibroma. The patient opted for MRI surveillance, which revealed interval growth 3 years later. Decompression surgery revealed only angiofibroma, but resection 9 months later demonstrated high\u2010grade sarcoma and concomitant angiofibroma. The patient had residual disease which progressed through chemoradiation, and is now pursuing clinical trial enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malignant transformation of nasopharyngeal angiofibroma is extremely rare. As highlighted by this report, high\u2010grade undifferentiated lesions may arise in tumors without previous radiation. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E2425\u2013E2427, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24378","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T18:53:04Z","timestamp":1454525584000},"source":"Crossref","is-referenced-by-count":9,"title":["High\u2010grade malignant transformation of a radiation\u2010na\u00efve nasopharyngeal angiofibroma"],"prefix":"10.1002","volume":"38","author":[{"given":"Jordan J.","family":"Allensworth","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H.","family":"Troob","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lanciault","sequence":"additional","affiliation":[{"name":"Department of Pathology Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600818138"},{"key":"e_1_2_5_3_1","first-page":"1122","article-title":"Expression of androgen receptors in nasopharyngeal angiofibroma: an immunohistochemical study of 24 cases","volume":"11","author":"Hwang HC","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.83"},{"issue":"10","key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1288\/00005537-198910000-00018","article-title":"Malignant transformation of a nasopharyngeal angiofibroma","volume":"99","author":"Makek MS","year":"1989","journal-title":"Laryngoscope"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459987908700112"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i5.973"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2012.08.010"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200104000-00022"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000162655.96247.66"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00027"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890020207"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812454394"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.01.007"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199008000-00001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041866"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/era.12.161"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:53:10Z","timestamp":1694310790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,3]]},"references-count":16,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/hed.24378"],"URL":"https:\/\/doi.org\/10.1002\/hed.24378","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,3]]}}}