{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T15:30:49Z","timestamp":1703604649184},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Controversy exists regarding the superiority of single photon emission CT (SPECT)\/CT over SPECT for preoperative localization of parathyroid adenomas in primary hyperparathyroidism (PHPT), as well as the cost\u2010effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was undertaken of patients undergoing surgery for PHPT from January 2009 to August 2014. Ultrasound and SPECT (ultrasound\u2010SPECT) or SPECT\/CT (ultrasound\u2010SPECT\/CT) were performed for each patient. Sensitivity and positive predictive value (PPV) of each modality were calculated. Cost\u2010effectiveness was determined by an incremental cost\u2010effectiveness ratio (ICER) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred fifty\u2010nine patients with 266 parathyroid adenomas were included in the study. Lateralization sensitivity and PPV of ultrasound\u2010SPECT were 85.1% and 98.2%, respectively. The lateralization sensitivity and PPV of ultrasound\u2010SPECT\/CT were 86.9% and 99.4%, respectively. A cost of $2499.22 (CAD) per additional parathyroid adenoma detection by ultrasound\u2010SPECT\/CT was determined from the ICER analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Similar sensitivities and PPVs were observed between ultrasound\u2010SPECT and ultrasound\u2010SPECT\/CT in preoperatively lateralizing parathyroid adenomas, with relatively equivalent cost\u2010effectiveness. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E2062\u2013E2065, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24379","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T15:55:19Z","timestamp":1454687719000},"source":"Crossref","is-referenced-by-count":4,"title":["Comparison of single photon emission CT (SPECT) with SPECT\/CT imaging in preoperative localization of parathyroid adenomas: A cost\u2010effectiveness analysis"],"prefix":"10.1002","volume":"38","author":[{"given":"Brittany","family":"Barber","sequence":"first","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Moher","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Dentistry University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dziegielewski","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic Surgery University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb126768.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0856-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199809)20:6<535::AID-HED8>3.0.CO;2-8"},{"key":"e_1_2_5_6_1","first-page":"295","article-title":"Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid; 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