{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:30:00Z","timestamp":1761823800816},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head & Neck"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a retrospective review of the National Cancer Database.<\/jats:p><\/jats:sec>Results<\/jats:title>Ten percent of all parotid cancers were PANOS (n<\/jats:italic> = 3155). Median age was 67 years. Most patients were men (62.8%) with high\u2010grade histology (67.2%). Regional metastasis was common (35.9%), whereas occult nodal metastasis (20.2% overall) was less frequent in non\u2010high\u2010grade lesions (8.5% vs 31.6%; p<\/jats:italic> < .001). Distant metastasis was rare (7.9%). Five\u2010year overall survival (OS) was 47%. In multivariate analysis, age, regional metastasis, distant metastasis, high\u2010grade, and T classification were predictors of lower survival. Patients with stage III to IV disease receiving surgery and radiotherapy had a better OS than those receiving surgery alone (51% vs 41%; p<\/jats:italic> < .001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>PANOS is an aggressive disease with frequent regional metastasis and low survival. Numerous variables are associated with worse survival. \u00a9 2016 Wiley Periodicals, Inc. Head Neck 38:1208\u20131212, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24382","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T05:18:17Z","timestamp":1462943897000},"page":"1208-1212","source":"Crossref","is-referenced-by-count":15,"title":["Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients"],"prefix":"10.1002","volume":"38","author":[{"given":"Kevin Y.","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sobia F.","family":"Khaja","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry A.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800270049013"},{"key":"e_1_2_6_3_1","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours","author":"Eveson JW","year":"2005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.06.017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.03.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080309"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23568"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2011.11.019"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.5858\/2004-128-1385-SANOSA","article-title":"Salivary adenocarcinoma, not otherwise specified: a collection of orphans","volume":"128","author":"Li J","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90416-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00007-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23249"}],"container-title":["Head & Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24382","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:13:23Z","timestamp":1696482803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,10]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/hed.24382"],"URL":"https:\/\/doi.org\/10.1002\/hed.24382","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,10]]}}}