{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:35:44Z","timestamp":1788068144185,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Project with Heavy Ions at the National Institute of Radiological Sciences (NIRS)-Heavy Ion Medical Accelerator in Chiba"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most cases of adenoid cystic carcinoma (ACC) of the tongue base are radioresistant, and are diagnosed in the advanced stage. Therefore, we evaluated the safety and efficacy of carbon ion radiotherapy (C\u2010ion RT) for locally advanced ACC of the tongue base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen patients with ACC of the tongue base were treated with C\u2010ion RT between May 2002 and April 2014. Seventeen patients had T4a disease and 1 patient had T2 disease before C\u2010ion RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period was 57 months (range, 10\u2013132 months). The 5\u2010year local control rate was 92%. The 5\u2010year overall survival (OS) and disease\u2010free survival (DFS) rates were 72% and 44%, respectively. Regarding late reactions, 2 patients developed grade 3 mandible osteoradionecrosis, and 1 had grade 3 hemorrhage of the tongue base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>C\u2010ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E2122\u2013E2126, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24397","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T14:57:07Z","timestamp":1454943427000},"source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base"],"prefix":"10.1002","volume":"38","author":[{"given":"Masashi","family":"Koto","sequence":"first","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Takagi","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Naganawa","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010etsu","family":"Mizoe","sequence":"additional","affiliation":[{"name":"Nagoya Proton Therapy Center Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Jingu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tohoku University School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Tsujii","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kamada","sequence":"additional","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chiba University School of Medicine Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Organizing Committee for the Working Group for Head and Neck Cancer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880310027006"},{"key":"e_1_2_5_3_1","first-page":"E475","article-title":"Adenoid cystic carcinoma of the tongue: case report and literature review","volume":"13","author":"Soares EC","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-1-15"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780120039002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90007-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870030054008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/60\/8\/3271"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys104"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.12.013"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.07.056"},{"key":"e_1_2_5_12_1","article-title":"Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear","author":"Koto M","year":"2014","journal-title":"Head Neck"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.09.009"},{"key":"e_1_2_5_14_1","volume-title":"TNM Classification of Malignant Tumours","author":"International Union Against Cancer (UICC)","year":"2002"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000308"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(80)80013-5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23505"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811412724"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20922"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-92"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4705357"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrt012"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10380"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109990338"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00445-9"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80721-4"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.10.007"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24397","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:02:42Z","timestamp":1694311362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,8]]},"references-count":26,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/hed.24397"],"URL":"https:\/\/doi.org\/10.1002\/hed.24397","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,8]]}}}