{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:21:20Z","timestamp":1771878080471,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5\/6 and p40. NUT protein immune\u2010stain positivity conclusively established the diagnosis of NUT midline carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Absence of well\u2010known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis. \u00a9 2016 Wiley Periodicals, Inc. Head Neck 38:E2471\u2013E2474, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24418","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:28:08Z","timestamp":1459380488000},"source":"Crossref","is-referenced-by-count":14,"title":["Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity"],"prefix":"10.1002","volume":"38","author":[{"given":"Ajay","family":"Kundra","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Brookdale University Hospital and Medical Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Andrei","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Brookdale University Hospital and Medical Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Westra","sequence":"additional","affiliation":[{"name":"Division of Pathology, Oncology, and Otolaryngology\/Head and Neck Surgery The Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashid","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\/Head and Neck Surgery Brookdale University Hospital and Medical Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Moussouris","sequence":"additional","affiliation":[{"name":"Division of Pathology Brookdale University Hospital and Medical Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Gohari","sequence":"additional","affiliation":[{"name":"Division of Radiology Brookdale University Hospital and Medical Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Brookdale University Hospital and Medical Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0479-3"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0235-x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20044"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010901)92:5<1195::AID-CNCR1438>3.0.CO;2-3"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1153"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.07.006"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e3181b5d84d"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-011-2272-3"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31821c9a23"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20755"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913123.2012.664613"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210852"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318198d666"},{"key":"e_1_2_4_15_1","first-page":"304","article-title":"BRD4\u2010NUT fusion oncogene: a novel mechanism in aggressive carcinoma","volume":"63","author":"French CA","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.17.6537-6549.2000"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011811-132438"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3513"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:14:44Z","timestamp":1696482884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,29]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/hed.24418"],"URL":"https:\/\/doi.org\/10.1002\/hed.24418","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,29]]}}}