{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:41:11Z","timestamp":1788392471166,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The contemporary treatment of oropharyngeal squamous cell carcinoma (SCC) is an area of debate. We report outcomes of a minimally invasive approach involving transoral laser microsurgery (TLM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A consecutive series of patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 153) undergoing primary TLM for oropharyngeal SCC from 2006 to 2013 was studied. Human papillomavirus (HPV) status was determined by p16 immunohistochemistry and high\u2010risk HPV DNA in situ hybridization. Survival analyses were evaluated using Kaplan\u2013Meier statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tumor subsites included tonsil (\n                      <jats:italic>n<\/jats:italic>\n                      = 94; 61.5%), tongue base (\n                      <jats:italic>n<\/jats:italic>\n                      = 38; 24.8%), and soft palate (\n                      <jats:italic>n<\/jats:italic>\n                      = 21; 13.7%), with the majority being American Joint Committee on Cancer (AJCC) stage III\/IVa (\n                      <jats:italic>n<\/jats:italic>\n                      = 124; 81.0%) and HPV\u2010positive (\n                      <jats:italic>n<\/jats:italic>\n                      = 101; 66.0%). Three\u2010year overall survival (OS), disease\u2010specific survival (DSS), and disease\u2010free survival (DFS) were 84.5%, 91.7%, and 78.2%, respectively. HPV\u2010positivity portended favorable oncologic outcomes. One\u2010year gastrostomy tube (G\u2010tube) dependency was 1.3%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      To the best of our knowledge, this is the largest single\u2010center TLM oropharyngeal SCC series to date. Our data suggest that TLM +\/\u2212 postoperative radiotherapy (PORT) results in at least as good oncologic outcomes as chemoradiotherapy (CRT), while conferring swallowing function advantages. \u00a9 2016 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      , 2016 \u00a9 2016 Wiley Periodicals, Inc. Head Neck 38:1263\u20131270, 2016\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.24432","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T12:01:53Z","timestamp":1459771313000},"page":"1263-1270","source":"Crossref","is-referenced-by-count":28,"title":["Transoral laser microsurgery for oropharyngeal squamous cell carcinoma: A paradigm shift in therapeutic approach"],"prefix":"10.1002","volume":"38","author":[{"given":"Mark D.","family":"Wilkie","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Aintree University Hospital NHS Foundation Trust Liverpool United Kingdom"},{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine University of Liverpool Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdeep S.","family":"Upile","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Aintree University Hospital NHS Foundation Trust Liverpool United Kingdom"},{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine University of Liverpool Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Aintree University Hospital NHS Foundation Trust Liverpool United Kingdom"},{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine University of Liverpool Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Aintree 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