{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:25:24Z","timestamp":1790007924782,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal mucosal melanoma is a rare neoplasm with a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis was conducted on 78 patients with localized sinonasal mucosal melanoma treated at Memorial Sloan Kettering Cancer Center (MSKCC from 1998\u20132013). Demographic, tumor, imaging, and treatment factors were recorded and survival and disease\u2010control outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median overall survival (OS) and disease\u2010specific survival (DSS) were 32 and 50 months, respectively. Median locoregional recurrence\u2010free survival (LRFS) and distant recurrence\u2010free survival (DRFS) were 43 and 12 months, respectively. Multivariate analysis demonstrated greater OS in nasal cavity tumors and earlier T classification. Radiotherapy (RT) was associated with significantly greater LRFS (5\u2010years; 35% vs 59%; <jats:italic>p<\/jats:italic> = .01), but no difference in OS. Post\u2010RT positron emission tomography (PET) response was associated with greater OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distant metastasis is the predominant mode of recurrence in sinonasal mucosal melanoma, but local recurrence remains common. RT is associated with improved local control, but no survival benefit. The prognostic value of post\u2010RT PET imaging warrants further investigation. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38:<\/jats:bold> 1310\u20131317, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24435","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T15:57:13Z","timestamp":1459785433000},"page":"1310-1317","source":"Crossref","is-referenced-by-count":80,"title":["Localized sinonasal mucosal melanoma: Outcomes and associations with stage, radiotherapy, and positron emission tomography response"],"prefix":"10.1002","volume":"38","author":[{"given":"Robert M.","family":"Samstein","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University 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