{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:09:12Z","timestamp":1776413352907,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National Institutes of Health grant from the National Cancer Institute","award":["(1K08CA154963-01A1 to A.G.S.)"],"award-info":[{"award-number":["(1K08CA154963-01A1 to A.G.S.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The majority of human papillomavirus (HPV)\u2010related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high\u2010risk non\u2010HPV16 genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of patients with high\u2010risk non\u2010HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high\u2010risk non\u2010HPV16 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010risk non\u2010HPV16 genotypes accounted for 9% of HPV\u2010related OPC. Of the 27 total high\u2010risk non\u2010HPV16 OPCs, HPV35 was most prevalent (48%). High\u2010risk non\u2010HPV16 OPC presented at a slightly higher age (<jats:italic>p<\/jats:italic> = .021) and higher clinical T classification (<jats:italic>p<\/jats:italic> = .008) compared to HPV16 OPC, but there was no significant survival difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical characteristics of high\u2010risk non\u2010HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi\u2010institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high\u2010risk HPV types. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38:<\/jats:bold> 1330\u20131337, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24442","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T07:53:46Z","timestamp":1460706826000},"page":"1330-1337","source":"Crossref","is-referenced-by-count":40,"title":["Clinical characteristics and outcomes of oropharyngeal carcinoma related to high\u2010risk non\u2013human papillomavirus16 viral subtypes"],"prefix":"10.1002","volume":"38","author":[{"given":"Indu","family":"Varier","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Baylor College of Medicine Houston TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brieze R.","family":"Keeley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Krupar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Baylor College of Medicine Houston TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Patsias","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University Oklahoma Health Sciences Center OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun K.","family":"Parasher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Genden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett A.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Icahn School of Medicine NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Bakst","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Icahn School of Medicine at Mount Sinai NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Icahn School of Medicine at Mount Sinai NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof J.","family":"Misiukiewicz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Icahn School of Medicine at Mount Sinai NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Y.","family":"Chiao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Health Services Research Baylor College of Medicine Houston TX, USA"},{"name":"Center for Innovations in Quality Effectiveness and Safety, Michael E. DeBakey VA Medical Center  Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Baylor College of Medicine Houston TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Laban","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Center Ulm, Department of Oto\u2010Rhino\u2010Laryngology and Head and Neck Surgery University Medical Center Ulm Ulm Baden\u2010W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Demicco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall R.","family":"Posner","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Icahn School of Medicine at Mount Sinai NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Sikora","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Baylor College of Medicine Houston TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70137-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.7662"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6136"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i6.172"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.03.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0406-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-4-1057"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23512"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115931"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.04.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27739"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182a577c7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.05.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.01.029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1990"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/437815"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0602-T"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.7.12.18282"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074797"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000694"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405044"}],"container-title":["Head &amp; 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