{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:30:41Z","timestamp":1771997441289,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T00:00:00Z","timestamp":1458864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recommended margins for thick cutaneous melanoma (Breslow thickness &gt;4 mm; T4) have decreased over recent decades. Optimal margins and the role of sentinel node biopsy (SNB) in thick head and neck melanoma remain controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center review was conducted of patients treated between 2002 and 2012 assessing the impact of excision margins and sentinel lymph node status on locoregional recurrence and melanoma\u2010specific survival (MSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eight patients were identified. Median age was 71.1 years and median Breslow thickness was 6.0 mm. Median follow\u2010up was 40 months. Locoregional recurrence occurred in 27% and there was no significant reduction in recurrence with margins \u22652 cm (<jats:italic>p<\/jats:italic> = .17). Increasing margins did not improve survival (<jats:italic>p<\/jats:italic> = .58). Fifty\u2010nine patients (55%) underwent SNB, of which 27% were positive. There was a trend toward longer survival for patients who were sentinel lymph node\u2010negative (<jats:italic>p<\/jats:italic> = .097).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Wider margins do not significantly improve locoregional recurrence or MSS. Sentinel lymph node involvement reflects a poor prognosis. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38:<\/jats:bold> 1373\u20131379, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24444","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T14:33:23Z","timestamp":1458916403000},"page":"1373-1379","source":"Crossref","is-referenced-by-count":10,"title":["Excision margins and sentinel lymph node status as prognostic factors in thick melanoma of the head and neck: A retrospective analysis"],"prefix":"10.1002","volume":"38","author":[{"given":"Olivia","family":"Ruskin","sequence":"first","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sanelli","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne 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