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Ongoing investigations are examining deintensified treatments for human papillomavirus (HPV)\u2010associated oropharyngeal SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Appropriateness Criteria panel, using modified Delphi methodology, produced a literature summary, an assessment of treatment recommendations, and cases to illustrate their use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A multidisciplinary team produces optimum results. Based on HPV status, smoking history, and staging, patients are divided into groups at low, intermediate, and high\u2010risk of death. In the future, treatment recommendations may be influenced by HPV status, which has changed the epidemiology of oropharyngeal SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T1 to T2N0M0 resectable oropharyngeal SCC can be treated with surgery or radiation without chemotherapy. Patients with T1\u20102N1\u20102aM0 disease can receive radiation, chemoradiation, or transoral surgery with neck dissection and appropriate adjuvant therapy. Patients with T1\u20102N2b\u20103M0 disease should receive chemoradiation or transoral surgery with neck dissection and appropriate adjuvant therapy. Concurrent chemoradiation is preferred for T3 to T4 disease. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38:<\/jats:bold> 1299\u20131309, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24447","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T18:44:21Z","timestamp":1466707461000},"page":"1299-1309","source":"Crossref","is-referenced-by-count":13,"title":["ACR Appropriateness Criteria<sup>\u00ae<\/sup> Locoregional therapy for resectable oropharyngeal squamous cell carcinomas"],"prefix":"10.1002","volume":"38","author":[{"given":"Jonathan J.","family":"Beitler","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Quon","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher U.","family":"Jones","sequence":"additional","affiliation":[{"name":"Radiological Associates of Sacramento Sacramento California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"Salama","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Busse","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Maimonides Cancer Center Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo A.","family":"Koyfman","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Ridge","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center Philadelphia Pennsylvania, American College of Surgeons"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil F.","family":"Saba","sequence":"additional","affiliation":[{"name":"Emory University Atlanta Georgia, American Society of Clinical Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard V.","family":"Smith","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center Bronx New York, American College of Surgeons"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Worden","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor Michigan, American Society of Clinical Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yao","sequence":"additional","affiliation":[{"name":"University Hospital Case Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-7476","authenticated-orcid":false,"given":"Sue S.","family":"Yom","sequence":"additional","affiliation":[{"name":"University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Expert Panel on Radiation Oncology \u2013 Head and Neck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"e_1_2_2_2_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology. 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