{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:27:03Z","timestamp":1780759623309,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate active surveillance strategy in the clinically negative neck in maxillary squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred fourteen consecutive patients diagnosed with oral maxillary SCC were analyzed retrospectively from 3 centers in The Netherlands. Analysis parameters included regional disease\u2010free survival of N0 patients stratified for T classification, elective radiotherapy (RT) of the neck; and overall survival of the whole cohort, stratified by N classification; salvage neck surgery rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the N0 cohort, 26.0% of the patients developed neck metastasis in the follow\u2010up visits. Regional recurrence was not related to T classification or postoperative RT of the neck. Regional and locoregional recurrence were associated with diminished overall survival (<jats:italic>p<\/jats:italic> &lt; .05). Regional metastasis was operable in 22 of 26 cases (85%). Only 1 patient presented with inoperable neck metastasis without local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Watchful waiting was feasible in this cohort. If meticulous follow\u2010up is not available, elective neck dissection is recommended. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38:<\/jats:bold> 1794\u20131798, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24511","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T12:28:38Z","timestamp":1467635318000},"page":"1794-1798","source":"Crossref","is-referenced-by-count":14,"title":["Management of the clinically N0 neck in squamous cell carcinoma of the maxillary alveolus and hard palate"],"prefix":"10.1002","volume":"38","author":[{"given":"Alejandra D. van","family":"Os","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute\u2013Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Karakullukcu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute\u2013Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ren\u00e9","family":"Leemans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery VU University Medical Centre and Cancer Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy B.","family":"Halmos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \/ Head and Neck Surgery University of Groningen, University Medical Center Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L. N.","family":"Roodenburg","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Groningen, University Medical Center Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn van","family":"Weert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery VU University Medical Centre and Cancer Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Hakki","family":"Karagozoglu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max J. H.","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Groningen, University Medical Center Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"113","article-title":"Elective neck dissection in oral carcinoma: a critical review of the evidence","volume":"27","author":"Kowalski LP","year":"2007","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.017"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00136-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2246::AID-CNCR7>3.0.CO;2-S"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000233607.41540.28"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20054"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21631"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/25125369"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.09.006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22957"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880310005001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21505"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2320-0"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00293-9"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21547"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506007"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.04.006"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.05.001"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:58:04Z","timestamp":1696330684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,4]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/hed.24511"],"URL":"https:\/\/doi.org\/10.1002\/hed.24511","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,4]]}}}