{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:12:34Z","timestamp":1770595954310,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T00:00:00Z","timestamp":1465862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>T2 glottic cancer with impaired vocal cord mobility (T2b) is known to have higher local failure rates when compared with T2 cancers without impaired cord mobility (T2a) treated with radiotherapy (RT) alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective review, we identified and compared the local control rates of 3 groups: T2aN0 treated with RT; T2bN0 treated with RT; and T2b\u20103N0\u20102 treated with chemoradiotherapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010year local control rate was 95.1% for T2aN0, 73.2% for T2bN0 treated with RT, and 91.5% for the CRT group (<jats:italic>p<\/jats:italic> = .01). On univariate analysis, T2bN0 disease versus T2aN0 treated with RT alone (<jats:italic>p<\/jats:italic> = .03) was significantly associated with inferior local control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with glottic cancer with impaired vocal cord mobility (T2b) have a high rate of local failure with RT alone. The addition of concurrent chemotherapy should be considered for patients highly motivated toward larynx preservation and willing to accept the potential toxicity. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38:<\/jats:bold> 1832\u20131836, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24520","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T15:29:36Z","timestamp":1465918176000},"page":"1832-1836","source":"Crossref","is-referenced-by-count":26,"title":["Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with Radiation alone"],"prefix":"10.1002","volume":"38","author":[{"given":"Priyanka","family":"Bhateja","sequence":"first","affiliation":[{"name":"Department of Medicine, Seidman Cancer Center University Hospitals, Case Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant H.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Intermountain Healthcare Murray Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Greskovich","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandana A.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobenna I.","family":"Nwizu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lamarre","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B.","family":"Burkey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Adelstein","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo A.","family":"Koyfman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800301)45:5<991::AID-CNCR2820450526>3.0.CO;2-D"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600202"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4559"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-193"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6097"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.12.027"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(92)90242-M"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(81)90078-X"},{"key":"e_1_2_6_10_1","unstructured":"WangCC.Carcinoma of the larynx. 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