{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:06:57Z","timestamp":1760472417263},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are still controversies about the therapeutic strategies and subsequent outcome in head and neck Merkel cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinicopathological data of 23 Merkel cell carcinomas, 93 cutaneous head and neck squamous cell carcinomas (HNSCCs), 126 malignant melanomas, and 91 primary parotid gland carcinomas were comprehensively analyzed. Merkel cell carcinomas were cytokeratin 20 (CK20)\/neuron\u2010specific enolase (NSE)\/chromogranin A (CgA)\/synaptophysin (Syn)\/thyroid transcription factor\u20101 (TTF\u20101)\/MIB1 immunostained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All Merkel cell carcinomas underwent wide local excision. Parotidectomy\/neck dissection was performed in 40%\/33% cutaneous Merkel cell carcinoma and 100%\/100% in parotid gland Merkel cell carcinoma. Five\u2010year recurrence\u2010free interval (RFI)\/overall survival (OS) was significantly higher in malignant melanoma (81\/80%) than in cutaneous Merkel cell carcinoma\/HNSCC. Interestingly, 5\u2010year RFI\/OS was significantly higher in Merkel cell carcinoma (61%\/79%) than in HNSCC (33%\/65%; <jats:italic>p<\/jats:italic> &lt; .0001) despite comparable TNM classifications and treatment regimens. There were neither differences of RFI\/OS between parotid gland Merkel cell carcinoma and parotid gland carcinomas, nor in the immunohistochemical profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Five\u2010year RFI\/OS was significantly better in cutaneous Merkel cell carcinoma when compared with TNM classification matched HNSCC. Five\u2010year RFI\/OS was comparable in parotid gland Merkel cell carcinoma and other primary parotid gland malignancies. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 92\u201397, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24540","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T14:36:49Z","timestamp":1469198209000},"page":"92-97","source":"Crossref","is-referenced-by-count":11,"title":["Clinicopathological characteristics of head and neck Merkel cell carcinomas"],"prefix":"10.1002","volume":"39","author":[{"given":"Andreas","family":"Knopf","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Hals\u2010Nasen\u2010Ohrenklinik und Poliklinik M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Bas","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen 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