{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:30:01Z","timestamp":1761823801132},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the rate of contralateral neck recurrence after surgery and unilateral neck radiotherapy, for lateralized tonsillar cancers with ipsilateral neck disease, in order to inform future clinical trial protocols for this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with lateralized tonsillar squamous carcinoma (T1\u2013T2, N0\u2013N2b), treated with surgery and unilateral adjuvant radiotherapy in a single United Kingdom center were retrospectively identified. Rates of recurrence in the contralateral, unirradiated neck were analyzed, together with survival and toxicity data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 81 patients included, after a median follow\u2010up of 5.7 years, no contralateral recurrences were identified. Five\u2010year overall survival, progression\u2010free survival, and locoregional control were 91.0%, 93.0%, and 95.4%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unilateral radiotherapy is an effective and safe treatment option for the postoperative management of lateralized tonsillar cancers, even in patients with N2b disease, and should be recommended in future clinical trial protocols. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 17\u201323, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24541","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T14:34:52Z","timestamp":1469025292000},"page":"17-23","source":"Crossref","is-referenced-by-count":28,"title":["Unilateral radiotherapy for surgically resected lateralized squamous cell carcinoma of the tonsil"],"prefix":"10.1002","volume":"39","author":[{"given":"Thomas Paul","family":"Rackley","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology Velindre Cancer Centre Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanangwa Clara","family":"Namelo","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Velindre Cancer Centre Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nachi","family":"Palaniappan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Velindre Cancer Centre Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Velindre Cancer Centre Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M. J.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospital of Wales Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mererid","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Velindre Cancer Centre Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2013.12.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.12.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.06.1975"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.03.049"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00051-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2013.31.2.66"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23297"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01613-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.048"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.03.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.06.005"},{"key":"e_1_2_6_13_1","unstructured":"NCT01950689.NIMRAD (a randomised placebo\u2010controlled trial of synchronous nimorazole versus radiotherapy alone in patients with locally advanced head and neck squamous cell carcinoma not suitable for synchronous chemotherapy or cetuximab) [Internet]. 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