{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:27Z","timestamp":1772118507704,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T00:00:00Z","timestamp":1474243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>National guidelines support surgical\u2010based treatment and offer nonsurgical therapy as an alternative for advanced\u2010stage oral cavity squamous cell carcinoma (SCC). There are limited data evaluating current utilization of these therapies and their survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 5856 patients were found in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with resectable advanced\u2010stage oral cavity SCC tumors. Outcomes were disease\u2010specific survival (DSS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Surgical therapy had significantly improved mean DSS and OS (115 and 71 months, respectively) compared to nonsurgical therapy (63 and 35 months, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001). The use of nonsurgical therapy was significantly associated with the hard palate, and patients who were single, divorced, and black, with T3, T4, and N3 tumors, and the percent utilization has significantly increased from 12% to 20% (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Utilization of nonsurgical therapy for advanced\u2010stage oral cavity SCC is increasing and is independently associated with a reduction in survival, as well as patient factors traditionally associated with reduced access to medical care and advanced T and N classifications. \u00a9 2016 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      <jats:bold>39:<\/jats:bold>\n                      82\u201391, 2017\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.24542","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T03:25:22Z","timestamp":1474255522000},"page":"82-91","source":"Crossref","is-referenced-by-count":22,"title":["Increasing use of nonsurgical therapy in advanced\u2010stage oral cavity cancer: A population\u2010based study"],"prefix":"10.1002","volume":"39","author":[{"given":"Richard B.","family":"Cannon","sequence":"first","affiliation":[{"name":"Otolaryngology Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin C.","family":"Sowder","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke O.","family":"Buchmann","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"},{"name":"Huntsman Cancer Hospital Salt Lake City Utah"},{"name":"Department of Surgery, Division Otolaryngology George E. Whalen VAMC Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"},{"name":"Huntsman Cancer Hospital Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying J.","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Hospital Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Hospital Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth F.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Hospital Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus M.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"},{"name":"Huntsman Cancer Hospital Salt Lake City Utah"},{"name":"Department of Surgery, Division Otolaryngology George E. 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