{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:36:36Z","timestamp":1788305796635,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004099","name":"la Ligue contre le Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This article reports risk factors and long\u2010term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents from a combined dataset from 3 consecutive international trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 140 children (9.3% of total) prospectively enrolled in the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP\u2010MMT)\u201084\/89\/95 studies were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary site was: superficial face in 46%; oral cavity (21%); neck (19%); and salivary glands (14%). Local control was achieved in 96%, but 49% relapsed (locoregionally 91%). At median follow\u2010up of 10 years, 5\u2010year overall survival (OS) was 74.7% (67.4% to 81.9%) and event\u2010free survival 48.9% (40.6% to 57.2%), although this improved with successive studies. Radiotherapy (RT) as first\u2010line treatment was independently prognostic for event\u2010free survival (relative risk [RR]\u2009=\u20090.4 [range, 0.2\u20130.7]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) even if it did not impact OS (RR\u2009=\u20091 [range, 0.5\u20132]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High rates of locoregional relapse were seen in head and neck rhabdomyosarcoma that should be prevented by more frequent use of RT in this primary. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 24\u201331, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24547","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T14:46:53Z","timestamp":1469544413000},"page":"24-31","source":"Crossref","is-referenced-by-count":27,"title":["Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies"],"prefix":"10.1002","volume":"39","author":[{"given":"Daniel","family":"Orbach","sequence":"first","affiliation":[{"name":"Adolescent and Pediatric Oncology Department Institut Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Mosseri","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Institut Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Gallego","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Pathology Department Royal Manchester Children's Hospital Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Devalck","sequence":"additional","affiliation":[{"name":"Pediatric Haematology Oncology Department Hopital Universitaire des enfants Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Brenann","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology Royal Manchester Children's Hospital Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max M.","family":"van Noesel","sequence":"additional","affiliation":[{"name":"Center of Pediatric Oncology Princess M\u00e1xima Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Institut d'Hematologie et d'Oncologie P\u00e9diatrique Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H. 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