{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:50:38Z","timestamp":1773201038245,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment for early\u2010stage tongue squamous cell carcinoma (SCC) is usually surgery alone. There is ambiguity regarding the impact of minor adverse features (MAFs) on outcome and the role of postoperative radiotherapy (PORT) in tongue SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed on 48 patients diagnosed with tongue SCC treated in our center. Patients with MAFs received adjuvant PORT. Disease outcome in patients with MAFs, and the effect of PORT were analyzed using the Kaplan\u2013Meier method and log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients had T1 and 17 had T2 disease. PORT was given to 7 patients with MAFs. Mean follow\u2010up time was 70 months. The 2\u2010year overall survival (OS) rate was 86%. Perineural invasion had a significant impact on disease\u2010free survival (DFS; <jats:italic>p<\/jats:italic> =.05). There was an improved DFS in patients with MAFs treated with PORT (<jats:italic>p<\/jats:italic> =.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MAFs may have an impact on outcome in tongue SCC, and PORT can improve disease outcome in these patients. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 147\u2013150, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24555","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T06:26:54Z","timestamp":1470810414000},"page":"147-150","source":"Crossref","is-referenced-by-count":16,"title":["Radiotherapy in early\u2010stage tongue squamous cell carcinoma with minor adverse features"],"prefix":"10.1002","volume":"39","author":[{"given":"Orna","family":"Katz","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Nachalon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ohad","family":"Hilly","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Shpitzer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Bachar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Limon","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Unit, Davidoff Cancer Center, Rabin Medical Center, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron","family":"Popovtzer","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Unit, Davidoff Cancer Center, Rabin Medical Center, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_5_3_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results (SEER) website. Available at:http:\/\/seer.cancer.gov\/data\/. Accessed2012."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<583::AID-HED4>3.0.CO;2-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(98)80055-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.09.058"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23206"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23110"},{"key":"e_1_2_5_9_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology \u2013 Head and Neck Cancers","author":"National Comprehensive Cancer Network","year":"2014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300621"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90302-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890070105"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24161"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-43"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00142-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.01.018"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90385-4"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890915)64:6<1195::AID-CNCR2820640606>3.0.CO;2-7"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860110057008"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050046"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26229"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080603"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24555","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:43:28Z","timestamp":1696401808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,10]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/hed.24555"],"URL":"https:\/\/doi.org\/10.1002\/hed.24555","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,10]]}}}