{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:57:40Z","timestamp":1779177460759,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health","award":["GR-2011-02349732"],"award-info":[{"award-number":["GR-2011-02349732"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Formalin\u2010fixed paraffin\u2010embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)\u2010based methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty\u2010four samples (28.9%) harbored mucosal HPVs: 3 oropharyngeal (6.9%), 15 oral (48.3%), 4 laryngeal (66.7%), and 2 nasopharyngeal papillomas (66.7%). Eighty\u2010one cases were also tested for cutaneous HPVs, detected in 16 lesions (19.7%): 11 (13.5%) harbored only cutaneous types, and 5 (6.2%) were positive for both cutaneous and mucosal HPVs. Among these 81 cases, prevalence of mucosal and\/or cutaneous HPV infection was 43.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV DNA detection in a fraction of head and neck papillomas supports the role of HPV in their development. However, other markers need to be considered to confirm the association of HPV infection with these lesions. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 254\u2013259, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24575","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T15:47:13Z","timestamp":1473695233000},"page":"254-259","source":"Crossref","is-referenced-by-count":20,"title":["Mucosal and cutaneous human papillomaviruses in head and neck squamous cell papillomas"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-1726","authenticated-orcid":false,"given":"Maria Gabriella","family":"Don\u00e0","sequence":"first","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatologic Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pichi","sequence":"additional","affiliation":[{"name":"Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rollo","sequence":"additional","affiliation":[{"name":"Pathology Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"Gheit","sequence":"additional","affiliation":[{"name":"Infections and Cancer Biology Group International Agency for Research on Cancer Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Laquintana","sequence":"additional","affiliation":[{"name":"Pathology Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Covello","sequence":"additional","affiliation":[{"name":"Pathology Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Pescarmona","sequence":"additional","affiliation":[{"name":"Pathology Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Spriano","sequence":"additional","affiliation":[{"name":"Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Pellini","sequence":"additional","affiliation":[{"name":"Otolaryngology Head Neck Surgery Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Giuliani","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatologic Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Tommasino","sequence":"additional","affiliation":[{"name":"Infections and Cancer Biology Group International Agency for Research on Cancer Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Benevolo","sequence":"additional","affiliation":[{"name":"Pathology Department, Regina Elena National Cancer Institute IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"182","volume-title":"World Health Organization classification of tumours. 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