{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:22:25Z","timestamp":1790295745425,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypoglossal nerve palsies are infrequent complications of head and neck radiotherapy. Treatments focus on maintaining function and prevention of abnormal airway\u2010related swallowing events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A patient with longstanding cranial neuropathies, including bilateral hypoglossal involvement, secondary to chemoradiotherapy for nasopharyngeal carcinoma, experienced repeated episodes of life\u2010threatening complications. Initially, 2 courses of 2 weekly 24\u2010hour intravenous methylprednisolone (IVMP) infusions were administered 2 years apart. We report the results of a third course comprising 5 weekly cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient\u2010reported outcomes revealed significant improvement in swallowing function, speech, and psychosocial status. Airway invasion during swallowing and pharyngeal retention were assessed videofluoroscopically and evaluated using the Penetration\u2010Aspiration Scale (PAS) and a residue rating scale, respectively. PAS ratings after infusions 2 and 5, improved dramatically from baseline and were maintained at 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High doses of IVMP may improve radiation\u2010induced neuropathies. Further testing in similar patients is needed to prove reproducibility. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> E23\u2013E28, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24600","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T18:17:52Z","timestamp":1476296272000},"source":"Crossref","is-referenced-by-count":13,"title":["High\u2010dose intravenous steroid regimen for radiation\u2010induced hypoglossal nerve palsy"],"prefix":"10.1002","volume":"39","author":[{"given":"Lachlan J.","family":"McDowell","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene C.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology, Oncology Program, Sunnybrook Odette Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Princess Margaret Cancer Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.02.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.12.028"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1990.tb136976.x"},{"issue":"3","key":"e_1_2_6_6_1","first-page":"259","article-title":"Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III","volume":"96","author":"Bracken MB","year":"2002","journal-title":"J Neurosurg"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009564"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00021291"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009610"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.2.1780393"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-012-9426-9"},{"key":"e_1_2_6_13_1","unstructured":"Normalized Residue Ratio Scale (NRSS) rating instructions. 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