{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:51:45Z","timestamp":1791924705677,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical perineural invasion (PNI) of the trigeminal and facial nerves from cutaneous head and neck squamous cell carcinoma (cutaneous HNSCC) is a rare clinical entity that poses unique therapeutic challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of a skull base oncology database was performed of patients with the diagnosis of clinical PNI from a cutaneous HNSCC. Patients who were previously untreated underwent multimodal treatment entailing surgical resection and postoperative radiotherapy (PORT) and patients who were previously treated with radiotherapy underwent salvage surgical resection between the years 2006 and 2012. Survival outcomes, such as disease\u2010free survival (DFS) and overall survival (OS), were analyzed and correlated with surgical factors, such as margin status, previous treatment, zone involvement, and trigeminal involvement (branch\u2010specific), as well as the pretreatment and posttreatment pain scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 21 patients with clinical PNI from cutaneous HNSCC, 7 patients (33%) were previously treated for their disease with primary radiotherapy. Negative tumor margins were achieved in 18 patients (86%). Three of the 7 patients (43%) undergoing salvage surgery had positive margins. One\u2010year and 3\u2010year DFS for previously untreated patients was 91% and 67%, respectively, whereas 1\u2010year and 3\u2010year DFS was 72% and 28%, respectively, for the previously treated patients. Previous radiotherapy, ophthalmic nerve involvement, and positive margins portended poorer survival outcomes in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The retrospective study of this rare clinical entity demonstrates that multimodal treatment can achieve favorable survival outcomes. \u00a9 2017 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39<\/jats:bold>: 1280\u20131286, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24607","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T06:36:55Z","timestamp":1493966215000},"page":"1280-1286","source":"Crossref","is-referenced-by-count":31,"title":["Clinical perineural invasion of the trigeminal and facial nerves in cutaneous head and neck squamous cell carcinoma: Outcomes and prognostic implications of multimodality and salvage treatment"],"prefix":"10.1002","volume":"39","author":[{"given":"Serkan","family":"Erkan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Savundra","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Fremantle Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Neuroradiology Unit Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanand N.","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery, School of Surgery, Fiona Stanley Hospital Campus University of Western Australia Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunesh P.","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery, School of Surgery, Fiona Stanley Hospital Campus University of Western Australia Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12282"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00086.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160103"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22509"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01095.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1984.tb01243.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90385-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0288-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20991"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21986"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10025"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10334"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01407-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23982"},{"key":"e_1_2_6_16_1","first-page":"301","volume-title":"AJCC Cutaneous squamous cell carcinoma and other cutaneous carcinomas. 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