{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:38:56Z","timestamp":1790699936450,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Medical Collaborative Innovation Project of Guangzhou City of China","award":["201400000001"],"award-info":[{"award-number":["201400000001"]}]},{"name":"National Science and Technology Pillar Program during the Twelfth Five-year Plan Period","award":["2014BAI09B10"],"award-info":[{"award-number":["2014BAI09B10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the predictive value of pretreatment serum uric acid (SUA) for metastasis in locally advanced nasopharyngeal carcinoma (NPC) treated with intensity\u2010modulated radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study examined 1063 patients with locally advanced NPC. Multivariate survival analysis was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High pretreatment SUA level (&gt;353.4 \u03bcmol\/L) independently predicted distant metastasis\u2010free survival (<jats:italic>p<\/jats:italic> = .013) and was associated with high white blood cell (<jats:italic>p<\/jats:italic> = .005), lymphocyte counts (<jats:italic>p<\/jats:italic> &lt; .001), and male sex (<jats:italic>p<\/jats:italic> &lt; 0.001). In addition, SUA levels were significantly elevated in patients with T1 to T3 classification (<jats:italic>p<\/jats:italic> = .042). For patients with subsequent lung metastases after treatment, markedly higher pretreatment SUA levels were detected compared with patients who had other distant metastases (<jats:italic>p<\/jats:italic> =.012) and patients without distant metastasis (<jats:italic>p<\/jats:italic> = .024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pretreatment SUA may be a useful biomarker for evaluating treatment options for patients with locally advanced NPC. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 39: 492\u2013497, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24631","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T15:53:38Z","timestamp":1482249218000},"page":"492-497","source":"Crossref","is-referenced-by-count":14,"title":["Use of pretreatment serum uric acid level to predict metastasis in locally advanced nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Xiao\u2010Jing","family":"Du","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Long","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key 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