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Diagnosis of HCCC was confirmed by fluorescence in situ hybridization (FISH) for <jats:italic>EWSR1<\/jats:italic>. Literature review was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 15 patients with HCCCs (10 women, 5 men), 13 with <jats:italic>EWSR1<\/jats:italic> rearrangement. Median age at diagnosis was 57 years (range, 31\u201387 years). Oral cavity (<jats:italic>n<\/jats:italic> = 9) and base of tongue (<jats:italic>n<\/jats:italic> = 4) were the most frequent primary sites. Combining our cases with those identified in literature review, the 10\u2010year risk of local recurrence and locoregional nodal metastasis were 49% and 15%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Molecularly confirmed HCCC accounted for 2.5% of salivary gland malignancies at our institution. HCCCs are indolent tumors with a propensity for locoregional recurrence. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 39: 503\u2013511, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24637","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T14:25:05Z","timestamp":1480429505000},"page":"503-511","source":"Crossref","is-referenced-by-count":36,"title":["Reappraising hyalinizing clear cell carcinoma: A population\u2010based study with molecular confirmation"],"prefix":"10.1002","volume":"39","author":[{"given":"Juan C.","family":"Hernandez\u2013Prera","sequence":"first","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simion","family":"Chiosea","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cordon\u2013Cardo","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Najfeld","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Demicco","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199401000-00007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197209)30:3<749::AID-CNCR2820300324>3.0.CO;2-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23974"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0244-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23902"},{"key":"e_1_2_6_7_1","first-page":"227","volume-title":"World Health Organization Classification of Tumours. 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