{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:24:43Z","timestamp":1790645083117,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to assess the efficacy and toxicities of reirradiation using intensity\u2010modulated radiotherapy (IMRT) in patients with locally advanced recurrent nasopharyngeal carcinoma (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight patients with consecutive rT3 to rT4 NPC treated between 2005 and 2013 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010year overall survival (OS), progression\u2010free survival (PFS), and local control rate were 47.2%, 17.5%, and 44.3%, respectively. Gross target volume (GTV) D<jats:sub>95<\/jats:sub>, GTV D<jats:sub>50<\/jats:sub>, and age were all important prognostic factors for OS and PFS, but only GTV D<jats:sub>95<\/jats:sub> was an important determinant for local control. A total of 73.7% patients experienced \u22651 grade 3 late toxicities and 3 patients died of massive epistaxis. Temporal lobe necrosis (TLN) developed sooner with a higher total biological equivalent dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adequate tumor dose coverage was important for treating rT3 to rT4 NPC. Although late complications were common, treatment\u2010related mortality was solely vascular in nature. Dose constraints of neurologic structures for reirradiation should be revised with the latest information on late toxicities. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 39: 533\u2013540, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24645","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T14:22:49Z","timestamp":1480429369000},"page":"533-540","source":"Crossref","is-referenced-by-count":60,"title":["Reirradiation with intensity\u2010modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Oscar S. H.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry C. K.","family":"Sze","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Pamela Youde Nethersole Eastern Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy L. K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy T. Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah W. 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