{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:20:19Z","timestamp":1791534019585,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T00:00:00Z","timestamp":1487980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>National guidelines support both surgical and radiotherapy (RT) as initial treatment options for early\u2010stage oral cavity squamous cell carcinoma (SCC). There remains limited data evaluating the survival outcomes of RT and the current practice patterns for these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of 8274 patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with T1 to T2N0M0 oral cavity SCC. Primary outcomes were 5\u2010year overall survival (OS) and disease\u2010specific survival (DSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgical therapy had significantly improved OS (140 months; <jats:italic>p<\/jats:italic> &lt; .001) and DSS (217 months; <jats:italic>p<\/jats:italic> &lt; .001) compared to surgery with adjuvant RT (104 and 163 months, respectively) and definitive RT (68 and 136 months, respectively). The use of radiation alone was associated with an increased T classification, hard palate, retromolar trigone primary site lesions, and advanced patient age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary radiation without surgery continues to be used in a subset of early\u2010stage oral cavity SCCs, in which it is associated with decreased OS and DSS. \u00a9 2017 Wiley Periodicals, Inc. Head Neck 39: 876\u2013880, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24679","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T07:03:15Z","timestamp":1488006195000},"page":"876-880","source":"Crossref","is-referenced-by-count":37,"title":["Treatment\u2010related determinants of survival in early\u2010stage (T1\u20132N0M0) oral cavity cancer: A population\u2010based study"],"prefix":"10.1002","volume":"39","author":[{"given":"Justin C.","family":"Sowder","sequence":"first","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke O.","family":"Buchmann","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"},{"name":"The Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Department of Surgery Division Otolaryngology, George E. Whalen Department of Veterans Affairs Medical Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"},{"name":"The Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"The Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Lloyd","sequence":"additional","affiliation":[{"name":"The Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth F.","family":"Grossmann","sequence":"additional","affiliation":[{"name":"The Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head and Neck Surgery The University of Utah School of Medicine Salt Lake City Utah"},{"name":"The Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Department of Surgery Division Otolaryngology, George E. Whalen Department of Veterans Affairs Medical Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_6_5_1","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results (SEER) program.Cancer Statistics Review. National Cancer Institute;2013. Available at:https:\/\/seer.cancer.gov\/. Accessed May 10 2016."},{"key":"e_1_2_6_6_1","unstructured":"National Comprehensive Cancer Network (NCCN).Head and neck cancers (version 2.2014). Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head\u2010and\u2010neck.pdf. 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