{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:55:01Z","timestamp":1768290901306,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous adnexal adenocarcinoma is a rare cancer that is occasionally human epidermal growth factor receptor\u20102 (HER\u20102)\u2010positive, and demonstrates variable response to HER\u20102 inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a case of adnexal adenocarcinoma of the scalp in a 56\u2010year\u2010old man. He underwent wide local excision with cervical node dissection followed by radiation, but had extensive local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pathology demonstrated a poorly differentiated adnexal adenocarcinoma with HER\u20102 overexpression by immunohistochemistry (IHC) and high HER\u20102 gene amplification by fluorescence in situ hybridization. The patient was treated with trastuzumab\u2010based therapy with dramatic response and clinical resolution of the tumor. Upon pausing trastuzumab, he developed local relapse, but had an excellent response to restarting trastuzumab monotherapy. He lacks visible disease 43 months after the initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We believe the exquisite sensitivity of the primary carcinoma and subsequent recurrence to trastuzumab therapy was due to strong HER\u20102 expression both at the protein and gene level. \u00a9 2017 Wiley Periodicals, Inc. Head Neck 39: E69\u2013E71, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24682","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T15:16:54Z","timestamp":1487776614000},"source":"Crossref","is-referenced-by-count":10,"title":["Cutaneous adnexal adenocarcinoma with exquisite sensitivity to trastuzumab"],"prefix":"10.1002","volume":"39","author":[{"given":"Timothy J.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Sher","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien A.","family":"Nedzi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall S.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad S.","family":"Beg","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Mull","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venetia R.","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.1.75"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.46"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2470152"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910383"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0369"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e3283484a60"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4285"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.1615"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0238"},{"key":"e_1_2_4_12_1","first-page":"5263","article-title":"Chemotherapy of rare skin adnexal tumors: a review of literature","volume":"34","author":"Iuliis F","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00570.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1354"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2507"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:57:51Z","timestamp":1696391871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/hed.24682"],"URL":"https:\/\/doi.org\/10.1002\/hed.24682","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]}}}