{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:03:06Z","timestamp":1777968186623,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Cleveland Veterans Affairs Medical Center, Cleveland, Ohio"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1002\/hed.24700","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T15:42:44Z","timestamp":1486482164000},"page":"E55-E60","source":"Crossref","is-referenced-by-count":8,"title":["Cyclical hypofractionated radiotherapy also known as \u201cQUAD Shot\u201d alone using intensity-modulated radiotherapy for squamous cell carcinoma of the parotid gland in an 85-year-old patient with multiple comorbidities"],"prefix":"10.1002","volume":"39","author":[{"given":"Whoon Jong","family":"Kil","sequence":"first","affiliation":[{"name":"Radiation Therapy Section, Radiology Service; Cleveland Veterans Affairs Medical Center; Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Camphausen","sequence":"additional","affiliation":[{"name":"Radiation Oncology Branch, National Cancer Institute; National Institutes of Health; Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,7]]},"reference":[{"key":"10.1002\/hed.24700-BIB0001|hed24700-cit-0001","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","article-title":"Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis","volume":"26","author":"Machtay","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1002\/hed.24700-BIB0002|hed24700-cit-0002","first-page":"339","volume-title":"Radiobiology for Radiologist","author":"Hall","year":"2002","edition":"5"},{"key":"10.1002\/hed.24700-BIB0003|hed24700-cit-0003","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0959-8049(00)00054-X","article-title":"Natural history of untreated head and neck cancer","volume":"36","author":"Kowalski","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1002\/hed.24700-BIB0004|hed24700-cit-0004","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1200\/JCO.2014.55.1143","article-title":"Role of radiation therapy in palliative care of the patient with cancer","volume":"32","author":"Lutz","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1002\/hed.24700-BIB0005|hed24700-cit-0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/02841869409083923","article-title":"Influence of late side-effects upon daily life after radiotherapy for laryngeal and pharyngeal cancer","volume":"33","author":"Jensen","year":"1994","journal-title":"Acta Oncol"},{"key":"10.1002\/hed.24700-BIB0006|hed24700-cit-0006","first-page":"121","volume-title":"In the fraction size in radiobiology and radiotherapy","author":"Sakamoto","year":"1974"},{"key":"10.1002\/hed.24700-BIB0007|hed24700-cit-0007","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1148\/118.1.175","article-title":"Short-course radiation therapy in the treatment of head and neck tumors","volume":"118","author":"Abramson","year":"1976","journal-title":"Radiology"},{"key":"10.1002\/hed.24700-BIB0008|hed24700-cit-0008","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.ijrobp.2016.03.010","article-title":"Palliative short-course radiation therapy in rectal cancer: a phase 2 study","volume":"95","author":"Picardi","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.24700-BIB0009|hed24700-cit-0009","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0360-3016(79)90727-2","article-title":"Unorthodox fractionation in the treatment of head and neck tumors","volume":"5","author":"Pilepich","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.24700-BIB0010|hed24700-cit-0010","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0360-3016(79)91212-4","article-title":"Whole pelvis megavoltage irradiation with single doses of 1000 rad to palliate advanced gynecologic cancers","volume":"5","author":"Boulware","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.24700-BIB0011|hed24700-cit-0011","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0167-8140(01)00282-1","article-title":"Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head and neck mucosal site treated with radiation therapy with palliative intent","volume":"59","author":"Erkal","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.24700-BIB0012|hed24700-cit-0012","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.radonc.2004.03.009","article-title":"Short course palliative radiotherapy of 20 Gy in 5 fractions for advanced and incurable head and neck cancer: AIIMS study","volume":"71","author":"Mohanti","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.24700-BIB0013|hed24700-cit-0013","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/hed.20894","article-title":"Palliative radiation therapy for head and neck cancer: toward an optimal fractionation scheme","volume":"30","author":"Chen","year":"2008","journal-title":"Head Neck"},{"key":"10.1002\/hed.24700-BIB0014|hed24700-cit-0014","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.radonc.2007.10.020","article-title":"Hypofractionated radiotherapy for the palliation of advanced head and neck cancer in patients unsuitable for curative treatment-\u201cHypo Trial","volume":"85","author":"Porceddu","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.24700-BIB0015|hed24700-cit-0015","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/hed.23219","article-title":"Hypofractionated palliative radiotherapy for advanced head and neck cancer: the IHF2SQ regimen","volume":"35","author":"Monnier","year":"2013","journal-title":"Head Neck"},{"key":"10.1002\/hed.24700-BIB0016|hed24700-cit-0016","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.radonc.2008.06.007","article-title":"Hypofractionated, palliative radiotherapy for advanced head and neck cancer","volume":"89","author":"Agarwal","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.24700-BIB0017|hed24700-cit-0017","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/02841860902740899","article-title":"Hypofractionated radiotherapy denoted as the \u201cChristie scheme\u201d: an effective means of palliating patients with head and neck cancer not suitable for curative treatment","volume":"48","author":"Al-mamgani","year":"2009","journal-title":"Acta Oncol"},{"key":"10.1002\/hed.24700-BIB0018|hed24700-cit-0018","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/0360-3016(87)90314-2","article-title":"Palliation of advanced pelvic malignant disease with large fraction pelvic radiation and misonidazole: final report of RTOG phase I\/II study","volume":"13","author":"Spanos","year":"1987","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.24700-BIB0019|hed24700-cit-0019","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0360-3016(94)90389-1","article-title":"Late effect of multiple daily fraction palliation schedule for advanced pelvic malignancies (RTOG 8502)","volume":"29","author":"Spanos","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.24700-BIB0020|hed24700-cit-0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0360-3016(93)90012-K","article-title":"Phase I-II study of multiple daily fractions for palliation of advanced head and neck malignancies","volume":"25","author":"Paris","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.24700-BIB0021|hed24700-cit-0021","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2005.10.008","article-title":"The \u2018QUAD SHOT\u2019--a phase II study of palliative radiotherapy for incurable head and neck cancer","volume":"77","author":"Corry","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.24700-BIB0022|hed24700-cit-0022","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.oraloncology.2015.07.011","article-title":"Palliative head and neck radiotherapy with the RTOG 8502 regimen for incurable primary or metastatic cancers","volume":"51","author":"Lok","year":"2015","journal-title":"Oral Oncol"},{"key":"10.1002\/hed.24700-BIB0023|hed24700-cit-0023","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1002\/hed.24700-BIB0024|hed24700-cit-0024","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Head & Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hed.24700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T02:55:54Z","timestamp":1625280954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24700"}},"subtitle":["QUAD Shot for elderly multiple comorbid patients with head and neck cancer"],"editor":[{"given":"Peter","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,7]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1002\/hed.24700","archive":["Portico"],"relation":{},"ISSN":["1043-3074"],"issn-type":[{"value":"1043-3074","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2,7]]}}}