{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:45:35Z","timestamp":1783183535973,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T00:00:00Z","timestamp":1489190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chondroradionecrosis (CRN) is an uncommon but significant complication of laryngeal radiotherapy that presents a diagnostic challenge to clinicians through its similarity in presentation to cancer recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred ninety\u2010four patients underwent primary, adjuvant, or salvage radiation for laryngeal cancer from 1991 to 2015 at the University of Wisconsin. Medical records were reviewed to identify and characterize patients with a diagnosis of CRN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 294 patients, 7 cases (2.4%) of CRN were identified. Development of CRN was associated with the presence of cartilage invasion by tumor (<jats:italic>p<\/jats:italic> = .038) and ongoing alcohol use postradiotherapy (<jats:italic>p<\/jats:italic> = .036). Additionally, a trend between development of CRN and ongoing smoking postradiotherapy was observed (<jats:italic>p<\/jats:italic> = .067).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnosis of CRN is challenging, and the likelihood of successful resolution is modest. A high premium should be placed on efforts directed at prevention, such as tobacco and alcohol cessation. \u00a9 2017 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 1189\u20131194, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24749","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T15:56:54Z","timestamp":1489247814000},"page":"1189-1194","source":"Crossref","is-referenced-by-count":19,"title":["Chondroradionecrosis of the larynx: 24\u2010year University of Wisconsin experience"],"prefix":"10.1002","volume":"39","author":[{"given":"Thomas G.","family":"Gessert","sequence":"first","affiliation":[{"name":"Division of Otolaryngology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Britt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin M. W.","family":"Maas","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Wieland","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Harari","sequence":"additional","affiliation":[{"name":"Department of Human Oncology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory K.","family":"Hartig","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03200240033009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100407"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900605"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1982.92.2.173"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947908800410"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.06.1264"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110311"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.7225"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100129731"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2009.2.3.115"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-014-0315-6"},{"key":"e_1_2_6_13_1","first-page":"711","article-title":"CT findings in chondroradionecrosis of the larynx","volume":"19","author":"Hermans R","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_14_1","first-page":"353","article-title":"Can positron emission tomography distinguish tumor recurrence from irradiation sequelae in patients treated for larynx cancer?","volume":"3","author":"Greven KM","year":"1997","journal-title":"Cancer J Sci Am"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.11.054"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.05.017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.054"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813503802"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.06.010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5072"},{"key":"e_1_2_6_22_1","first-page":"103","article-title":"Hyperbaric oxygen therapy in the treatment of complications of irradiation in head and neck area","volume":"32","author":"Narozny W","year":"2005","journal-title":"Undersea Hyperb Med"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600101"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199809000-00005"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:24:44Z","timestamp":1695731084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/hed.24749"],"URL":"https:\/\/doi.org\/10.1002\/hed.24749","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,11]]}}}