{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:52:47Z","timestamp":1784631167116,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention Research Institute of Texas","doi-asserted-by":"publisher","award":["RP120941"],"award-info":[{"award-number":["RP120941"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54 CA136404"],"award-info":[{"award-number":["U54 CA136404"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The lymphatic vasculature provides a route for cancer metastases, and its dysfunction after cancer treatment can result in lymphedema. However, changes in the lymphatics before, during, and after surgery and radiation remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Near\u2010infrared fluorescence lymphatic imaging was performed before and after lymph node dissection and fractionated radiotherapy to assess changes in external lymphatic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who underwent both lymph node dissection and radiotherapy developed lymphatic dermal backflow on treated sides ranging from days after the start of radiotherapy to weeks after its completion, whereas contralateral regions that were not associated with lymph node dissection but also treated with radiotherapy experienced no such changes in external lymphatic anatomies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The external lymphatics undergo transient changes during and weeks after lymph node dissection and radiotherapy. \u00a9 2017 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 1177\u20131188, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24750","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T15:30:43Z","timestamp":1488814243000},"page":"1177-1188","source":"Crossref","is-referenced-by-count":29,"title":["Longitudinal monitoring of the head and neck lymphatics in response to surgery and radiation"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-6899","authenticated-orcid":false,"given":"John C.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Center for Molecular Imaging The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chih","family":"Tan","sequence":"additional","affiliation":[{"name":"Center for Molecular Imaging The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa B.","family":"Aldrich","sequence":"additional","affiliation":[{"name":"Center for Molecular Imaging The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Maus","sequence":"additional","affiliation":[{"name":"Center for Molecular Imaging The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel I.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron J.","family":"Karni","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Sevick\u2013Muraca","sequence":"additional","affiliation":[{"name":"Center for Molecular Imaging The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0205"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2014.07.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs629"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00535.2009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-64-768-1140"},{"key":"e_1_2_6_7_1","volume-title":"Foldi's Textbook of Lymphology for Physicians and Lymphedema Therapists","author":"F\u00f6ldi M","year":"2006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.01.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.03.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21538"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0476-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106034"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116152108"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.6.C1812"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2016.0018"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2009.01.009"},{"key":"e_1_2_6_17_1","first-page":"1211","article-title":"The destructive effect of radiation on lymphatic tissue","volume":"26","author":"Congdon CC","year":"1966","journal-title":"Cancer Res"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060589"},{"key":"e_1_2_6_19_1","first-page":"219","article-title":"Immune effects of targeted radiation therapy for cancer","volume":"19","author":"Sridharan V","year":"2015","journal-title":"Discov Med"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.02.009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.05.015"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-196840"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21253"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1188\/11.ONF.E1-E10"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23084"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12535"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070962"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:25:24Z","timestamp":1695731124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/hed.24750"],"URL":"https:\/\/doi.org\/10.1002\/hed.24750","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,6]]}}}