{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:22:14Z","timestamp":1740104534538,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the effect of fraction size on laryngoesophageal dysfunction among patients treated by chemoradiotherapy for laryngeal and hypopharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients underwent chemoradiotherapy for stage III\/IV squamous cell carcinomas of the larynx and hypopharynx. Median radiation dose was 70 Gy (range, 69.3\u201370.4 Gy) with daily fractionation ranging from 2 Gy to 2.2 Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When comparing 2 Gy versus &gt;2 Gy daily fractionation, there was no difference in 2\u2010year overall survival (71% vs 72%; <jats:italic>p<\/jats:italic> = .68), locoregional control (79% vs 77%; <jats:italic>p<\/jats:italic> = .43), or laryngectomy\u2010free survival (60% vs 61%; <jats:italic>p<\/jats:italic> = .72). Use of 2 Gy versus &gt;2 Gy fractionation improved laryngoesophageal dysfunction\u2010free survival (2\u2010year estimates, 49% vs 27%; <jats:italic>p<\/jats:italic> = .07). Patient\u2010reported voice and swallowing were improved with the former.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As the importance of a functional larynx becomes recognized as an endpoint for patients treated by voice preservation, the results of our study help refine treatment guidelines. \u00a9 2017 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39<\/jats:bold>: 1322\u20131326, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24757","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T18:21:45Z","timestamp":1489688505000},"page":"1322-1326","source":"Crossref","is-referenced-by-count":7,"title":["Effect of daily fraction size on laryngoesophageal dysfunction after chemoradiation for squamous cell carcinomas of the larynx and hypopharynx"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-712X","authenticated-orcid":false,"given":"Allen M.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of California \u2013 Los Angeles, David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California \u2013 Los Angeles, David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Meshman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California \u2013 Los Angeles, David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California \u2013 Los Angeles, David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Beron","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California \u2013 Los Angeles, David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Abemayor","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, University of California \u2013 Los Angeles David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maie","family":"St. John","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, University of California \u2013 Los Angeles David Geffen School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1200\/JCO.2012.43.6097"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.3109\/00016480902914080"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1093\/jnci\/88.13.890"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1002\/hed.21081"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1007\/978-0-387-88441-7"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2294::AID-CNCR17>3.0.CO;2-S"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1200\/JCO.2007.14.8841"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1002\/cncr.26066"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1016\/j.oraloncology.2016.03.014"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1016\/j.ijrobp.2009.01.058"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1016\/j.amjoto.2006.12.002"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1016\/0360-3016(82)90517-X"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1080\/09553008914551931"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1016\/0360-3016(92)90975-N"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.1016\/S0167-8140(86)80061-5"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1016\/j.ijrobp.2009.03.079"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.1016\/S0360-3016(97)00284-8"},{"doi-asserted-by":"publisher","key":"e_1_2_5_19_1","DOI":"10.1016\/j.ijrobp.2005.06.014"},{"doi-asserted-by":"publisher","key":"e_1_2_5_20_1","DOI":"10.1200\/JCO.2007.14.6647"},{"doi-asserted-by":"publisher","key":"e_1_2_5_21_1","DOI":"10.1016\/j.ijrobp.2007.05.056"}],"container-title":["Head &amp; 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