{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:48:44Z","timestamp":1793782124596,"version":"4.6.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Body mass index (BMI) has been associated variably with head and neck cancer outcomes. We evaluated the association between BMI at either diagnosis or at early adulthood head and neck cancer outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with invasive head and neck squamous cell cancer at Princess Margaret Cancer Centre in Toronto, Canada, were surveyed on tobacco and alcohol exposure, performance status, comorbidities, and BMI at diagnosis. A subset also had data collected for BMI at early adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 2.5 years, in 1279 analyzed patients, being overweight (hazard ratio [HR], 0.55; 95% confidence interval [CI], 0.4\u20130.8; <jats:italic>p<\/jats:italic> = .001) at diagnosis was associated with improved survival when compared with individuals with normal weight. In contrast, underweight patients at diagnosis were associated with a worse outcome (HR, 1.89; 95% CI, 1.2\u20133.1; <jats:italic>p<\/jats:italic> &lt; .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Being underweight at diagnosis was an independent, adverse prognostic factor, whereas being overweight conferred better prognosis. BMI in early adulthood was not associated strongly with head and neck cancer outcomes. \u00a9 2017 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>39:<\/jats:bold> 1226\u20131233, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24760","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T08:57:38Z","timestamp":1490173058000},"page":"1226-1233","source":"Crossref","is-referenced-by-count":81,"title":["Body mass index and prognosis in patients with head and neck cancer"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-8958","authenticated-orcid":false,"given":"Ricardo Ribeiro","family":"Gama","sequence":"first","affiliation":[{"name":"Head and Neck Surgery Department Barretos Cancer Hospital Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Song","sequence":"additional","affiliation":[{"name":"Biostatistics Department Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biostatistics Department Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Catherine","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery University Health Network and University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Habbous","sequence":"additional","affiliation":[{"name":"Department of Medicine Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Medicine Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-4388","authenticated-orcid":false,"given":"Shao Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre, University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Biostatistics Department Princess Margaret Cancer 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