{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:38:04Z","timestamp":1770824284331,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sassella Foundation"},{"name":"Promedica Foundation"},{"name":"KFSP Tumor Oxygenation of the University of Zurich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to analyze the role of p16<jats:sup>INK4a<\/jats:sup> and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed from 1995 to 2014 were included in this study. Assessment of p16<jats:sup>INK4a<\/jats:sup> and HPV\u2010DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16<jats:sup>INK4a<\/jats:sup> positivity was defined as unequivocal nuclear and cytoplasmic staining of \u226570% of the cells, whereas 50%\u201069% was considered to be a \u201cborderline\u201d result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 46 patients with SCCs of the nasal vestibule, of whom 31 (67.4%) were available for p16<jats:sup>INK4a<\/jats:sup> and 30 (65.2%) for analysis of HPV. Expression of p16<jats:sup>INK4a<\/jats:sup> was present in 19.4% and showed coincidence with high\u2010risk HPV (<jats:italic>P<\/jats:italic> &lt; .001). Neither p16<jats:sup>INK4a<\/jats:sup> nor HPV\u2010DNA had significant impact on outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant immunoreactivity for p16<jats:sup>INK4a<\/jats:sup> was present in about one\u2010fifth of the samples and figured as a surrogate marker of high\u2010risk HPV infection. There was no influence on outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24767","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T17:25:25Z","timestamp":1490721925000},"page":"1392-1398","source":"Crossref","is-referenced-by-count":5,"title":["p16<sup>INK4a<\/sup>: A surrogate marker of high\u2010risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0967-934X","authenticated-orcid":false,"given":"Domenic","family":"Vital","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Zurich University Hospital and University of Zurich Frauenklinikstrasse 24 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Holzmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Zurich University Hospital and University of Zurich Frauenklinikstrasse 24 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard F.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Zurich University Hospital and University of Zurich Frauenklinikstrasse 24 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Soyka","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Zurich University Hospital and University of Zurich Frauenklinikstrasse 24 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Moch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology Zurich University Hospital and University of Zurich Schmelzbergstrasse 12 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter R.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology Zurich University Hospital and University of Zurich Schmelzbergstrasse 12 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Ikenberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology Zurich University Hospital and University of Zurich Schmelzbergstrasse 12 CH\u20108091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23549"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100119425"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(88)90052-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2007.01353.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10023"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21132"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90293-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1974.00780040012002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.120.3.595"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<100::AID-CNCR2820380118>3.0.CO;2-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90129-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24391"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8080075"},{"key":"e_1_2_6_15_1","first-page":"255","volume-title":"A Review of Human Carcinogens","author":"International Agency for Research on Cancer","year":"2009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00187-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00617-9"},{"key":"e_1_2_6_18_1","first-page":"444","article-title":"Original site of cervical carcinoma; 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