{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:20:35Z","timestamp":1788438035089,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate prognostic factors, locoregional control, and survival in locally advanced bucco\u2010alveolar complex cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 83 patients treated between January 2009 and December 2012 with bucco\u2010alveolar complex cancers was conducted. All patients had surgery and adjuvant radiotherapy with intensity\u2010modulated radiotherapy (IMRT) with\/without concurrent chemotherapy. Survival analysis was performed using Kaplan\u2010Meier and multivariable Cox regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On univariate and multivariate analysis, perineural invasion (PNI) was found to be an independent adverse risk factor. Patients with PNI\u2010positive disease had significantly worse 2\u2010year disease\u2010free survival (DFS), locoregional failure free survival, and overall survival (OS) as compared to patients with PNI\u2010negative disease (<jats:italic>P<\/jats:italic> &lt; 0. 001, 0.001 and &lt; 0. 001) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with patients with PNI\u2010negative disease, patients with PNI\u2010positive disease had much worse outcome despite aggressive adjuvant treatment. It warrants escalation of therapy and modification in radiation portals to cover neural pathways in patients with PNI\u2010positive disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24792","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T06:43:40Z","timestamp":1493361820000},"page":"1446-1453","source":"Crossref","is-referenced-by-count":14,"title":["Significance of perineural invasion in locally advanced bucco alveolar complex carcinomas treated with surgery and postoperative radiation \u00b1 concurrent chemotherapy"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-1419","authenticated-orcid":false,"given":"Anil Kumar","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Max Super Speciality Hospital Saket New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Max Super Speciality Hospital Patparganj New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Gulia","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Max Super Speciality Hospital Saket New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Max Super Speciality Hospital Patparganj New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotika","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Max Super Speciality Hospital Patparganj New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harit","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Max Super Speciality Hospital Saket New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajyoti","family":"Hazarika","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Max Super Speciality Hospital Saket New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urmi","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Pathology Max Super Speciality Hospital Saket New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Medical Physics Max Super Speciality Hospital Patparganj New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Bansal","sequence":"additional","affiliation":[{"name":"Division of Medical Physics Max Super Speciality Hospital Saket New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"International Agency for Research on Cancer.GLOBOCAN 2012(2012).http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_population.aspx. 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