{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:34:54Z","timestamp":1777534494740,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cavernous sinus syndrome presents as unilateral ophthalmoplegia associated with sympathetic denervation, pain, paresthesias, and V1 and V2 distribution numbness. The etiology may be vascular, inflammatory, infectious, and, less commonly, neoplastic (metastatic).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a patient with incomplete cavernous sinus syndrome as the initial manifestation of previously undetected metastatic prostate adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 59\u2010year\u2010old man presented with a 2\u2010month history of left hemicranial headaches with ptosis and binocular diplopia. Clinical evaluation found left third, fourth, and sixth cranial nerve palsy with mydriasis and ptosis. An MRI showed an enhancing lesion at the clivus with infiltration of left cavernous sinus. A trans\u2010sphenoidal biopsy was performed, leading to diagnosis of metastatic prostate adenocarcinoma. The patient underwent treatment and achieved clinical improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In middle\u2010aged men, it is important to include metastatic prostate adenocarcinoma in the differential diagnosis of cavernous sinus syndrome, even in the absence of primary tumor diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24808","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T06:42:46Z","timestamp":1493966566000},"source":"Crossref","is-referenced-by-count":6,"title":["Incomplete cavernous sinus syndrome as the initial manifestation of a previously undetected metastatic prostate adenocarcinoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Mar\u00eda","family":"Mach\u00edo Castell\u00f3","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-4704","authenticated-orcid":false,"given":"Diego","family":"Escobar Montatixe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cenjor Espa\u00f1ol","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Miguel","family":"Villacampa Aub\u00e1","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Montoya Bord\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Carias Calix","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"S\u00e1ez Pinel","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"184","volume-title":"Localization in clinical neurology","author":"Brazis PW","year":"2011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0630-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1348027"},{"issue":"3","key":"e_1_2_5_5_1","first-page":"149","article-title":"Sixth nerve palsy as the initial presenting sign of metastatic cancer. A case report and review of the literature","volume":"12","author":"O'Boyle JE","year":"1992","journal-title":"J Clin Neuroophthalmol."},{"key":"e_1_2_5_6_1","first-page":"87","volume-title":"Cancer neurology in clinical practice","author":"Newton HB","year":"2002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20553"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900201)65:3<586::AID-CNCR2820650333>3.0.CO;2-P"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:43:55Z","timestamp":1696538635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,5]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/hed.24808"],"URL":"https:\/\/doi.org\/10.1002\/hed.24808","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,5]]}}}