{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:32:01Z","timestamp":1770283921613,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to assess whether different tongue positions change the radiation doses to swallowing organs at risks: the pharyngeal constrictor, oral cavity, and larynx during intensity\u2010modulated radiotherapy (IMRT) for base of tongue (BOT) cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IMRT plans with Tongue\u2010out (IMRT\u2010TO) and tongue\u2010in position (IMRT\u2010TI) was compared in 3 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Distance from BOT to pharyngeal constrictor was increased to 1.8 \u00b1 0.8 cm with IMRT\u2010TO from 0.9 \u00b1 0.6 cm with IMRT\u2010TI (<jats:italic>P<\/jats:italic> &lt; .01). Compared to IMRT\u2010TI, IMRT\u2010TO significantly decreased the radiation dose to the anterior oral cavity, oral tongue, superior pharyngeal constrictor, middle pharyngeal constrictor, and supraglottic larynx (all <jats:italic>P<\/jats:italic> \u2264 .04). IMRT\u2010TO also had a smaller volume irradiated than IMRT\u2010TI to the anterior oral cavity and the oral tongue receiving \u226530 Gy (V30) and V35, and superior pharyngeal constrictor and middle pharyngeal constrictor for V55 and V65 (all <jats:italic>P<\/jats:italic> \u2264 .04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dosimetric advantage with IMRT\u2010TO over IMRT\u2010TI may potentially reduce post\u2010IMRT swallowing dysfunction in selected patients with BOT cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24809","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T15:26:42Z","timestamp":1493998002000},"source":"Crossref","is-referenced-by-count":5,"title":["Tongue\u2010out versus tongue\u2010in position during intensity\u2010modulated radiotherapy for base of tongue cancer: Clinical implications for minimizing post\u2010radiotherapy swallowing dysfunction"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-2949","authenticated-orcid":false,"given":"Whoon Jong","family":"Kil","sequence":"first","affiliation":[{"name":"Cleveland Veterans Affairs Medical Center Cleveland Ohio"},{"name":"Medicine Service\u2010Radiation Oncology Section Oklahoma City Veterans Affairs Medical Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kulasekere","sequence":"additional","affiliation":[{"name":"Cleveland Veterans Affairs Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Hatch","sequence":"additional","affiliation":[{"name":"Cleveland Veterans Affairs Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Bugno","sequence":"additional","affiliation":[{"name":"Cleveland Veterans Affairs Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Derrwaldt","sequence":"additional","affiliation":[{"name":"Cleveland Veterans Affairs Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.04.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.06.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.07.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.08.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.09.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.10.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.11.009"},{"issue":"33","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"53029","DOI":"10.18632\/oncotarget.10621","article-title":"Decreased radiation doses to tongue with \u201cstick\u2010out\u201d tongue position over neutral tongue position in head and neck cancer patients who refused or could not tolerate an intraoral device (bite\u2010block, tongue blade, or mouthpiece) due to trismus, gag reflex, or discomfort during intensity\u2010modulated radiation therapy","volume":"7","author":"Kil WJ","year":"2016","journal-title":"Oncotarget."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-199812000-00008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.02.049"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.067"},{"key":"e_1_2_8_15_1","volume-title":"Radiation techniques and targeting. 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